RecruitingNot ApplicableNCT06644846

Spatially Fractionated Radiation Treatment for Gynaecological Cancers

A Prospective Study of Spatially Fractionated Radiation Treatment Using Rapid Rod Technique for Gynaecological Cancers


Sponsor

Tata Memorial Hospital

Enrollment

20 participants

Start Date

Oct 4, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This is a prospective study to evaluate in-field disease control, survival and late toxicity in patients with cervical cancer or pelvic recurrence treated with spatially fractionated RT. The study will include patients with primary cervical cancer or pelvic recurrence not suitable for brachytherapy in view of anticipated or actual suboptimal target coverage due to aberrant anatomy or large residual disease at the time of brachytherapy.


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is evaluating a specialized radiation technique called spatially fractionated radiation therapy (SFRT) for women with gynecological cancers — such as cervical or endometrial cancer — who cannot receive standard internal radiation (brachytherapy) due to complex anatomy, large tumors, or other medical challenges. **You may be eligible if...** - You have cervical cancer after external radiation but brachytherapy is not technically feasible (e.g., due to unusual anatomy, large remaining tumor, or a very narrow vaginal canal) - You have inoperable endometrial cancer unsuitable for anesthesia or with poor brachytherapy coverage expected - You have a large pelvic recurrence after prior treatment that cannot be treated with surgery or brachytherapy - You have medical contraindications that make brachytherapy under anesthesia too risky **You may NOT be eligible if...** - You have an existing fistula (abnormal connection) in the bladder or rectum - You have a pelvic prosthesis - You refuse to provide consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATIONSpatially fractionated radiation therapy

Spatially fractionated" radiation therapy (SFRT) enables delivery of high-dose radiation to discrete sub-volumes inside a tumour target while restricting the remainder of the target to a safer lower dose. This technique results in generation of intentionally heterogeneous dose distribution with spatial areas of "hot" and "cold" spots within the tumour, thereby sparing nearby organs at risk.


Locations(1)

ACTREC Tata Memorial Centre

Navi Mumbai, Maharashtra, India

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NCT06644846


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