A Trial Comparing High-Flow Nasal Cannula Versus Noninvasive Ventilation on Reintubation and Post-Extubation Respiratory Failure in High-Risk Patients With Systolic Heart Failure

This study compares two breathing support methods — high-flow nasal cannula (warm, humidified oxygen delivered through a nose tube) versus noninvasive ventilation (a face mask that pushes air into the lungs) — for preventing breathing failure and re-intubation after patients with heart failure are taken off a breathing machine (extubated). **You may be eligible if...** - You are 18 or older - You have been on a ventilator for more than 24 hours - You have heart failure with reduced pumping function (ejection fraction ≤ 40%) **You may NOT be eligible if...** - You are being treated for a COPD flare-up or have high carbon dioxide levels in your blood - You are agitated or uncooperative - You have a do-not-resuscitate order - You have a tracheostomy or face anatomy that prevents using a breathing mask - You are a prisoner - You removed your own breathing tube - You already use noninvasive ventilation at home (e.g., for sleep apnea) Talk to your doctor to see if this trial is right for you.