Respiratory Failure Clinical Trials

65 recruiting

Respiratory Failure Trials at a Glance

148 actively recruiting trials for respiratory failure are listed on ClinicalTrialsFinder across 6 cities in 47 countries. The largest study group is Not Applicable with 73 trials, with the heaviest enrollment activity in Toronto, Istanbul, and Beijing. Lead sponsors running respiratory failure studies include Unity Health Toronto, Laval University, and Assistance Publique - Hôpitaux de Paris.

Browse respiratory failure trials by phase

Treatments under study

About Respiratory Failure Clinical Trials

Looking for clinical trials for Respiratory Failure? There are currently 65 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Respiratory Failure trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Respiratory Failure clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 148 trials

Recruiting

Brain-lung Interaction During Acute Respiratory Failure

Acute Respiratory Failure
Assistance Publique - Hôpitaux de Paris25 enrolled2 locationsNCT07279831
Recruiting
Not Applicable

Management of Post-operative Respiratory Failure by Using NIV and High Velocity Nasal Insufflation (HVNI)

Respiratory Failure Without HypercapniaRespiratory Failure With HypercapniaPostoperative Respiratory Complication
Assiut University180 enrolled1 locationNCT06988111
Recruiting

A Clinical Study for Developing Artificial Intelligence(AI)-Based Clustering Model for Personalized Medicine in Acute Respiratory Failure

Acute Respiratory Failure
Samsung Medical Center250 enrolled1 locationNCT06479421
Recruiting
Not Applicable

Effects of PBMT-sMF in Mechanically Ventilated Patients

Respiratory Failure
University of Nove de Julho112 enrolled1 locationNCT06454006
Recruiting
Not Applicable

Supraglottic Airway for Resuscitation in Preemies

Respiratory Failure
University of Pennsylvania20 enrolled1 locationNCT07419438
Recruiting

Comparison of the Efficacy and Safety of Ciprofol Versus Propofol for Sedation in ICU Patients Undergoing Non-Invasive Ventilation

Respiratory FailureCritical Illness
Nanfang Hospital, Southern Medical University1,680 enrolled1 locationNCT07536750
Recruiting

The Feasibility of Pulmonary Perfusion Assessment Using Sodium Bicarbonate Contrast With Electrical Impedance Tomography: A Prospective Pilot Study

Acute Respiratory Distress Syndrome (ARDS)Acute Respiratory FailurePneumonia+2 more
First Affiliated Hospital of Wannan Medical College41 enrolled1 locationNCT07542366
Recruiting
Not Applicable

Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients

Respiratory FailureHypoxiaAcute Hypoxemic Respiratory Failure+3 more
University of Colorado, Denver3,600 enrolled1 locationNCT06501118
Recruiting
Not Applicable

Non-invasive Ventilation Versus High Flow Oxygen

Pneumonia-associated Acute Hypoxemic Respiratory Failure
Niguarda Hospital128 enrolled1 locationNCT03758508
Recruiting
Not Applicable

Impact on Mortality of a Strategy Including Continuous Positive Airway Pressure Plus High Flow Nasal Cannula Oxygen Therapy Versus High Flow Nasal Cannula Oxygen Therapy Alone in Patients With de Novo Acute Hypoxemic Respiratory Failure: a Prospective, Randomized Controlled Trial.

De Novo Hypoxemic Acute Respiratory Failure (hARF)
Assistance Publique - Hôpitaux de Paris1,084 enrolled29 locationsNCT06213168
Recruiting

Benefit of Sleep Quality Monitoring by EEG in ICU

Respiratory Failure
University Hospital, Rouen47 enrolled1 locationNCT07522450
Recruiting
Phase 2

Transpulmonary Assessment for Individualized Lung Optimization in Obese Patients

Respiratory Failure
University of Alberta30 enrolled2 locationsNCT07359261
Recruiting
Not Applicable

Low and High Flow Suctioning in Intubated Infants

Respiratory Failure
Columbia University30 enrolled1 locationNCT06443970
Recruiting
Not Applicable

Noninvasive Technique and High Flow Nasal Oxygen in Respiratory Failure

Respiratory Failure
Minia University75 enrolled1 locationNCT07521254
Recruiting
Not Applicable

Physiological Study of High PEEP in Noninvasive Ventilation

Respiratory Failure With Hypoxia
Chongqing Medical University50 enrolled1 locationNCT07503509
Recruiting
Not Applicable

Diaphragmatic Physiology Similarity Index May Titrate HFNC Flow Setting: A Prospective Observational Study

Respiratory Failure
Sir Run Run Shaw Hospital100 enrolled2 locationsNCT06996665
Recruiting

Exhaled Breath Condensate Analysis in Mechanically Ventilated Patients

Acute Respiratory FailureCritical Illness
The Institute of Molecular and Translational Medicine, Czech Republic200 enrolled2 locationsNCT06189924
Recruiting
Not Applicable

Comparison of Two SpO2 Targets With Two Different Oximeters - Impact on FiO2 During Nasal High Flow Oxygen Therapy

Acute Respiratory FailureOxygen DeliveryHigh Flow Oxygen Therapy+1 more
Laval University30 enrolled1 locationNCT07168213
Recruiting
Not Applicable

Impact of PEEP on Respiratory Effort During Assisted Ventilation

Respiratory FailureMechanical VentilationEffort
Pontificia Universidad Catolica de Chile12 enrolled1 locationNCT07437846
Recruiting
Phase 3

Optimizing Pain Treatment in Children On Mechanical Ventilation

Mechanical VentilationSedation and AnalgesiaAnalgesics, Opioid+1 more
Weill Medical College of Cornell University644 enrolled15 locationsNCT06994442