Respiratory Failure Clinical Trials

173 recruitingLast updated: June 18, 2026

There are 173 actively recruiting respiratory failure clinical trials across 51 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 4. Top locations include Toronto, Ontario, Canada, New York, New York, United States, Beijing, Beijing Municipality, China. Updated daily from ClinicalTrials.gov.


Respiratory Failure Trials at a Glance

173 actively recruiting trials for respiratory failure are listed on ClinicalTrialsFinder across 6 cities in 51 countries. The largest study group is Not Applicable with 86 trials, with the heaviest enrollment activity in Toronto, New York, and Beijing. Lead sponsors running respiratory failure studies include Laval University, Unity Health Toronto, and Assistance Publique - Hôpitaux de Paris.

Browse respiratory failure trials by phase

Treatments under study

About Respiratory Failure Clinical Trials

Looking for clinical trials for Respiratory Failure? There are currently 69 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Respiratory Failure trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Respiratory Failure clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 173 trials

Recruiting
Not Applicable

Simulation Trial of Telemedical Support for Paramedics

Acute Respiratory FailureEmergenciesCardiopulmonary Arrest+1 more
Boston Medical Center420 enrolled9 locationsNCT06441760
Recruiting
Phase 2

A Clinical Trial of Early Ventilation in Amyotrophic Lateral Sclerosis (EVENT ALS)

Chronic respiratory failureNon-invasive ventilationRespiratory Insufficiency+7 more
University of Pennsylvania48 enrolled3 locationsNCT07071935
Recruiting

ICU Background Early Awareness for Critical deterioratiON

MortalityRespiratory FailureOrgan Failure, Multiple+2 more
ETH Zurich1,962 enrolled1 locationNCT07119411
Recruiting
Not Applicable

Effect of High Flow Nasal Therapy (HFNC) Weaning Protocols vs Standard of Care on Respiratory Outcomes in Patients With Acute Respiratory Failure

Acute Respiratory Failure (ARF)
University of Milan148 enrolled2 locationsNCT07638293
Recruiting

Predicting High-Flow Nasal Cannula Failure in Acute Hypoxemic Respiratory Failure Using Metabolomics and Clinical Data

Acute Hypoxemic Respiratory Failure
Hospital del Mar Research Institute (IMIM)300 enrolled1 locationNCT07607080
Recruiting
Not Applicable

Targeting prEssure-Muscle-index to Avoid Ventilatory Over-Assistance During Pressure Support Ventilation

Mechanical Ventilation ComplicationAcute Hypoxemic Respiratory Failure
Centre for Medical Sciences36 enrolled1 locationNCT06921655
Recruiting
Phase 4

Eduction in ImmunoSuppressive Regimen Among Kidney Transplant Recipients Patients Admitted to the Intensive Care Unit for Septic Shock and/or Acute Respiratory Failure

Acute Respiratory FailureKidney Transplant RecipientsSepsis and septic shock+1 more
University Hospital, Strasbourg, France212 enrolled1 locationNCT06881927
Recruiting

Investigating Health Related Quality of Life in Patients With Chronic Respiratory Failure

Chronic Obstructive Pulmonary DiseaseRespiratory FailureNeuromuscular Diseases+1 more
Guy's and St Thomas' NHS Foundation Trust200 enrolled1 locationNCT04236726
Recruiting
Not Applicable

A Trial Comparing High-Flow Nasal Cannula Versus Noninvasive Ventilation on Reintubation and Post-Extubation Respiratory Failure in High-Risk Patients With Systolic Heart Failure

Respiratory FailureSystolic Heart Failure
Yale University50 enrolled1 locationNCT06671015
Recruiting
Not Applicable

Non-Invasive Ventilation Versus High-flow Nasal Oxygen in Intensive Care Units

Post Extubation Respiratory Failure
Poitiers University Hospital670 enrolled47 locationsNCT05686850
Recruiting
Not Applicable

Monitoring Respiratory Muscle Function in Acute Respiratory Failure Patients on Non Invasive Respiratory Support

Non-invasive ventilationAcute Respiratory Failure (ARF)
Queen Mary University of London50 enrolled2 locationsNCT07423338
Recruiting

Association Between EIT and CT During PEEP Titration in Patients With Acute Respiratory Failure

Acute Hypoxemic Respiratory FailureVentilation, Mechanical
Istituto Clinico Humanitas30 enrolled1 locationNCT07175194
Recruiting
Not Applicable

Evaluation of Perfusion and Ventilation Distribution in Children: a Pilot Study.

Acute Respiratory Failure
Hospices Civils de Lyon20 enrolled1 locationNCT07532811
Recruiting
Phase 3

Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome

Respiratory FailureAcute Respiratory Distress Syndrome
Beth Israel Deaconess Medical Center1,100 enrolled33 locationsNCT06066502
Recruiting

Benefit of Sleep Quality Monitoring by EEG in ICU

Respiratory Failure
University Hospital, Rouen47 enrolled1 locationNCT07522450
Recruiting

Evaluation and Optimization of Telephone Triage Using Artificial Intelligence (AI) Models for the Detection of Demands for Time-dependent Pathology at the Emergency and Urgent Care Coordination Center (CCUE).

comaRespiratory FailureChest Pain+2 more
Centro de Emergencias Sanitarias 061 Andalucía5,000,000 enrolled1 locationNCT07247669
Recruiting

Waveform Capnography Compared to Colorimetric Carbon Dioxide Detection During Tracheal Intubation of Critically Ill Adults

Acute Respiratory Failure
Brian Driver2,092 enrolled9 locationsNCT06934876
Recruiting
Not Applicable

Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients

Respiratory FailureHypoxiaAcute Hypoxemic Respiratory Failure+3 more
University of Colorado, Denver3,600 enrolled1 locationNCT06501118
Recruiting

A New Tool for Extubation Readiness in Mechanically Ventilated Patients: Readiness for EXtubation Score

extubation failureRespiratory FailureWeaning Invasive Mechanical Ventilation+5 more
Medipol University470 enrolled7 locationsNCT07098611
Recruiting
Not Applicable

EIT-Guided Respiratory Physiotherapy for Prolonged Mechanical Ventilation (PMV)

Prolonged Mechanical VentilationRespiratory FailureCritical Illness
Capital Medical University200 enrolled1 locationNCT07372794