Study of the Safety, Tolerability, Electrophysiological Effects and Efficacy of DMT in Humans

This study is examining the safety, tolerability, and effects of DMT (dimethyltryptamine), a naturally occurring psychedelic compound, in healthy human volunteers and people with certain conditions. Researchers are studying how it affects brain electrical activity and whether it may have therapeutic potential. **You may be eligible if...** - You are between 21 and 65 years old - You are in good general health with a BMI between 18 and 35 - You speak English and can give informed consent - You are willing to avoid alcohol and recreational drugs the day before, day of, and day after each session - Women of childbearing potential must use effective contraception **You may NOT be eligible if...** - You have a personal or family history of psychosis, schizophrenia, or bipolar disorder - You have cardiovascular problems or a history of seizures - You are taking medications that interact with serotonin (like certain antidepressants) - You test positive on a drug screen on the day of a session Talk to your doctor to see if this trial is right for you.