Major Depression Disorder Clinical Trials

8 recruitingLast updated: June 18, 2026

There are 8 actively recruiting major depression disorder clinical trials across 5 countries. Studies span Not Applicable, Phase 1. Top locations include Ann Arbor, Michigan, United States, Atlanta, Georgia, United States, Bellaire, Texas, United States. Updated daily from ClinicalTrials.gov.


Major Depression Disorder Trials at a Glance

8 actively recruiting trials for major depression disorder are listed on ClinicalTrialsFinder across 6 cities in 5 countries. The largest study group is Not Applicable with 5 trials, with the heaviest enrollment activity in Ann Arbor, Atlanta, and Bellaire. Lead sponsors running major depression disorder studies include Gulhane Training and Research Hospital, Ionclinics & Deionic SL, and Deepak C. D'Souza.

Browse major depression disorder trials by phase

Treatments under study

About Major Depression Disorder Clinical Trials

Looking for clinical trials for Major Depression Disorder? There are currently 6 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Major Depression Disorder trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Major Depression Disorder clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 18 of 8 trials

Recruiting
Phase 1

Study of the Safety, Tolerability, Electrophysiological Effects and Efficacy of DMT in Humans

DepressionMajor Depression Disorder
Deepak C. D'Souza60 enrolled1 locationNCT06671977
Recruiting
Not Applicable

Accelerated High-Dose tDCS for Depression

Major DepressionMajor Depression Disorders
Medical University of South Carolina20 enrolled1 locationNCT07226011
Recruiting

An Examination of the Performance of QbMobile in Differential Diagnosis Associated With ADHD Symptoms

Social Anxiety DisorderAutism Spectrum Disorder (ASD)Major Depression Disorders+3 more
Qbtech AB300 enrolled1 locationNCT07329673
Recruiting
Not Applicable

Home tDCS for the Treatment of Major Depression.

Major Depression Disorder
Ionclinics & Deionic SL198 enrolled3 locationsNCT07510880
Recruiting
Not Applicable

Transcranial Photobiomodulation (tPBM) for Somatic Symptoms in Treatment-Resistant Depression

Treatment Resistant Depression (TRD)Major Depression Disorder
Taipei Veterans General Hospital, Taiwan40 enrolled1 locationNCT07543328
Recruiting
Not Applicable

Neuromodulation and Attention Deficits in MDD

Major Depression DisorderCognitive DeficitsSelective Attention
University of Electronic Science and Technology of China60 enrolled1 locationNCT07111169
Recruiting
Not Applicable

Molecular Signatures of TMS Response in Treatment-Resistant Depression

Major Depression Disorder
Gulhane Training and Research Hospital55 enrolled2 locationsNCT07039370
Recruiting

The OBSERVE Protocol

Major Depression Disorder
Yale University450 enrolled6 locationsNCT06725277