RecruitingNCT06681935

Defining Mechanisms of Surgical Site Infection After Oral Cancer Surgery

Sponsor

Medical College of Wisconsin

Enrollment

40 participants

Start Date

Apr 29, 2025

Study Type

OBSERVATIONAL

Conditions

Oral Cancer

Summary

The study design is an observational cohort study of patients undergoing standard of care oral cavity reconstruction. An observational study is required to prospectively evaluate microbial and antibiotic mechanisms underlying surgical site infection after oral cavity reconstruction.

Eligibility

Min Age: 21 Years

Plain Language Summary

Simplified for easier understanding

This study investigates why surgical site infections happen after reconstructive surgery for oral (mouth) cancer, by examining bacteria, immune responses, and other factors in wound samples during and after the operation. **You may be eligible if...** - You are 21 or older - You are scheduled for oral cavity reconstruction surgery that connects the mouth to the neck and uses a tissue flap (free or regional) - You have a history of oral or throat (oropharyngeal) cancer - You are receiving the standard antibiotic (ampicillin/sulbactam) as part of your surgical preparation **You may NOT be eligible if...** - You are allergic to ampicillin/sulbactam - You are pregnant or incarcerated Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREOral Cavity Reconstruction

This procedure includes a planned surgical connection from the oral cavity to the neck soft tissues which is repaired through free or pedicled flap reconstruction.