Oral Cancer Clinical Trials

38 recruitingLast updated: June 17, 2026

There are 38 actively recruiting oral cancer clinical trials across 13 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 3. Top locations include Taipei, Taiwan, Guangzhou, Guangdong, China, New York, New York, United States. Updated daily from ClinicalTrials.gov.


Oral Cancer Trials at a Glance

38 actively recruiting trials for oral cancer are listed on ClinicalTrialsFinder across 6 cities in 13 countries. The largest study group is Not Applicable with 20 trials, with the heaviest enrollment activity in Taipei, Guangzhou, and New York. Lead sponsors running oral cancer studies include National Taiwan University Hospital, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, and Centre hospitalier de l'Université de Montréal (CHUM).

Browse oral cancer trials by phase

Treatments under study

About Oral Cancer Clinical Trials

Looking for clinical trials for Oral Cancer? There are currently 37 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Oral Cancer trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Oral Cancer clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 38 trials

Recruiting
Phase 2

Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer

Head and Neck CarcinomaHead and Neck CancerOral Cancer+1 more
Case Comprehensive Cancer Center30 enrolled1 locationNCT06627270
Recruiting
Not Applicable

Mandibular Reconstruction Preplanning (ViPMR)

Oral CancerOral Cavity Cancer
University of British Columbia420 enrolled1 locationNCT05429099
Recruiting

Defining Mechanisms of Surgical Site Infection After Oral Cancer Surgery

Oral Cancer
Medical College of Wisconsin40 enrolled1 locationNCT06681935
Recruiting

Relationship Between Mouth Opening and Masseter Elasticity in Oral Cancer

Oral Cancer
National Taiwan University Hospital10 enrolled1 locationNCT06941727
Recruiting
Phase 1

Brodalumab in the Treatment of Immune-Related Adverse Events

Breast CancerLiver CancerEsophageal Cancer+15 more
Brian Henick, MD11 enrolled1 locationNCT06673329
Recruiting
Not Applicable

Surgeon-performed Ultrasound for Real-time Guidance In Oral Cancer Surgeries - A Multicenter Randomized Controlled Trial

Oral CancerTongue CancerSquamous Cell Carcinoma of the Oral Cavity or Oropharynx
Tobias Todsen150 enrolled7 locationsNCT07203911
Recruiting
Not Applicable

Enhancing Oral Cancer Awareness

PreventionOral CancerOral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity Cancer+3 more
Virginia Commonwealth University60 enrolled1 locationNCT06682494
Recruiting
Not Applicable

Tongue Proactive Strengthening Exercise Program Following Partial/Hemi Glossectomy and Reconstruction

Head and Neck CancerOral Cancer
Case Comprehensive Cancer Center40 enrolled1 locationNCT07110142
Recruiting
Not Applicable

Prosthesis Guided Speech Rehabilitation of T1/T2 Cancers of the Tongue

Oral CancerTongue NeoplasmsTongue Cancer
University of Michigan40 enrolled1 locationNCT02584270
Recruiting
Not Applicable

Develop and Evaluate An Artificial Intelligence Assisted Prehabilitation Program for Returning to Work and Cost-effectiveness Analysis in Patients With Oral Cancer

PhysiotherapyQuality of LifePrehabilitation+11 more
Taipei Veterans General Hospital, Taiwan650 enrolled5 locationsNCT07562100
Recruiting

Clinical and Molecular Features of Oral Premalignancy and Oral Cancer

Oral Cancer
M.D. Anderson Cancer Center1,000 enrolled1 locationNCT06550050
Recruiting
Not Applicable

Evaluation of Two Non-Invasive Methods, High-Resolution Microendoscopy and Liquid-Based Cytology, for Detection of Oral Precancer

Oral CancerOral PrecancerOral Cancer Screening
Anil Chaturvedi400 enrolled1 locationNCT07260344
Recruiting

AI-based Physiotherapy Evaluation System for Range of Motion in Oral Cancer Patients

Oral CancerAI (Artificial Intelligence)
National Taiwan University Hospital20 enrolled1 locationNCT07509619
Recruiting
Not Applicable

AI-based Physiotherapy for Oral Cancer Patients

Oral Cancer
National Taiwan University Hospital100 enrolled2 locationsNCT06785051
Recruiting

Microbiome in Head and Neck Squamous Cell Carcinoma

Head and Neck CancerOral CancerLip Cancer+1 more
University of Colorado, Denver60 enrolled1 locationNCT05837221
Recruiting

Estimating Jaw, Neck, and Shoulder Range of Motion Using an AI Model

Oral Cancer
National Taiwan University Hospital40 enrolled1 locationNCT06629038
Recruiting
Not Applicable

Effect of Dezocine Versus Nalbuphine Combined With Sufentanil on Postoperative Analgesia, Complications, and Free Flap Survival in Patients Undergoing Oral Cancer Radical Surgery: A Randomized Controlled Clinical Trial.

Oral CancerPostoperative Pain ManagementMouth Neoplasms+1 more
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University60 enrolled1 locationNCT07401641
Recruiting
Not Applicable

AI Based Physiotherapy 3- and 9-Month Follow-Up in Oral Cancer Patients

Oral Cancer
National Taiwan University Hospital65 enrolled1 locationNCT07237672
Recruiting
Not Applicable

Circulating Tumor Cell Counts in Postoperative ENE-Positive Oral Cavity Cancer Patients After Adjuvant CCRT

Head and Neck CancerOral Cancer
Chang Gung Memorial Hospital100 enrolled1 locationNCT07296250
Recruiting
Not Applicable

Defining TRPV4 Contribution of Schwann Cells to Oral Cancer Pain

Oral CancerSquamous Cell Carcinoma
New York University80 enrolled1 locationNCT07095608