Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms

This study tests whether a non-invasive capsule-based screening method can detect Barrett's esophagus — a pre-cancerous condition of the esophagus — in people who don't have typical heartburn symptoms but are at elevated risk. **You may be eligible if...** - You are 50 years or older - You do not have regular heartburn or reflux symptoms and are not on heartburn medications - You have at least 2 additional risk factors for Barrett's esophagus: abdominal obesity, a significant smoking history, being white, being male, or having a family history of Barrett's esophagus or esophageal cancer - You are scheduled for a routine colonoscopy - You have not had an upper endoscopy (a camera down the throat) in the past 10 years - You do not take blood thinners that cannot be stopped temporarily **You may NOT be eligible if...** - You have had an upper endoscopy in the past 10 years - You have known esophageal varices, strictures, or a history of esophageal/stomach surgery - You have difficulty or pain swallowing - You are on anticoagulants that cannot be paused - You have weekly or more frequent heartburn symptoms Talk to your doctor to see if this trial is right for you.