Gastroesophageal Reflux Clinical Trials

17 recruiting

Gastroesophageal Reflux Trials at a Glance

34 actively recruiting trials for gastroesophageal reflux are listed on ClinicalTrialsFinder across 6 cities in 19 countries. The largest study group is Not Applicable with 20 trials, with the heaviest enrollment activity in Kansas City, Naples, and Cleveland. Lead sponsors running gastroesophageal reflux studies include Mayo Clinic, Federal State Budgetary Scientific Institution "Federal Research Centre of Nutrition, Biotechnology, and Midwest Biomedical Research Foundation.

Browse gastroesophageal reflux trials by phase

Treatments under study

About Gastroesophageal Reflux Clinical Trials

Looking for clinical trials for Gastroesophageal Reflux? There are currently 17 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Gastroesophageal Reflux trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Gastroesophageal Reflux clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 34 trials

Recruiting
Not Applicable

Safety and Effectiveness of eGERD Device to Reduce Gastroesophageal Reflux Disease (GERD) Symptoms

GERD (Gastroesophageal Reflux Disease)
Gerd Care Medical Ltd84 enrolled4 locationsNCT06613438
Recruiting
Phase 3

Domperidone in Treating Patients With Gastrointestinal Disorders

Nausea and VomitingGastroparesisDyspepsia+4 more
M.D. Anderson Cancer Center200 enrolled1 locationNCT01696734
Recruiting

Esophageal Cancer Risk Registry

Esophageal CancerEsophageal DiseasesEsophageal Achalasia+2 more
University of Pittsburgh7,000 enrolled1 locationNCT00260585
Recruiting
Not Applicable

Mechanistic and Clinical Outcomes of a Surgical Innovation Aimed at Minimizing GERD Associated With VSG (INNOVATE-VSG)

ObesityBariatric SurgeryGastroesophageal Reflux Disease+1 more
University of California, Irvine44 enrolled2 locationsNCT06783751
Recruiting
Not Applicable

Performance and Safety of Afluxin® in Patients With Gastroesophageal Reflux Disease

Gastroesophageal Reflux Disease (GERD)
Devintec Sagl208 enrolled7 locationsNCT06984484
Recruiting

Study on Hydrotalcite for Relief of Acid Symptoms Due to Acid Rebound After Stopping Long-Term PPI Therapy

Gastroesophageal Reflux
Bayer167 enrolled2 locationsNCT07291700
Recruiting
Not Applicable

Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty Versus Esophagogastric Anastomosis for Gastric Cancer

Gastric CancerProximal Gastric AdenocarcinomaGastroesophageal Reflux Disease
Nanchong Central Hospital60 enrolled1 locationNCT05514769
Recruiting
Not Applicable

Evaluating Medication Adherence of Patients With Gastroesophageal Reflux Disease With Support of the Smartphone Application GERDCare

GERD (Gastroesophageal Reflux Disease)
Institute of Gastroenterology and Hepatology, Vietnam380 enrolled1 locationNCT07125521
Recruiting
Not Applicable

Compassionate Use of Domperidone for Refractory Gastroparesis

GastroparesisGastroesophageal RefluxGERD
Jose Cocjin20 enrolled1 locationNCT04699591
Recruiting
Not Applicable

External UES Band (Shaker Pressure Band) and GERD

Gastroesophageal Reflux
Medical College of Wisconsin350 enrolled1 locationNCT05697393
Recruiting
Not Applicable

Post-sleeve Gastrectomy Gastroesophageal Reflux Disease Prediction

Gastroesophageal RefluxSleeve GastrectomyBariatric Surgery Complication
Mayo Clinic200 enrolled2 locationsNCT04411823
Recruiting
Not Applicable

A Study of Breath Testing for Small Intestinal Bacterial Overgrowth

Gastroesophageal RefluxRegurgitationHeartburn
Mayo Clinic50 enrolled1 locationNCT05976165
Recruiting
Phase 2

A Study to Check the Safety of Dexlansoprazole and Learn if it Can Treat Symptomatic Nonerosive Gastroesophageal Reflux Disease in Children 2 to 11 Years Old

Gastroesophageal Reflux Disease (GERD)
Takeda70 enrolled33 locationsNCT02616302
Recruiting
Not Applicable

TLSA Versus TBSA Surgical Approach for Hiatal Hernia With Gastroesophageal Reflux Disease

GERD (Gastroesophageal Reflux Disease)Hernia, Hiatal
Beijing Friendship Hospital143 enrolled2 locationsNCT07252115
Recruiting
Phase 4

Treatment of Gastroesophageal Reflux Disease in Infants

Gastroesophageal RefluxInfant, Newborn, Diseases
Odense University Hospital96 enrolled3 locationsNCT06255886
Recruiting
Not Applicable

Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms

Esophageal AdenocarcinomaBarrett EsophagusGastroesophageal Reflux
Case Comprehensive Cancer Center800 enrolled5 locationsNCT06687603
Recruiting
Not Applicable

The Influence of Specialized Food Products Based on Ice-Cream on Esophageal Motility

GERD (Gastroesophageal Reflux Disease)Ineffective Esophageal Motility
Federal State Budgetary Scientific Institution "Federal Research Centre of Nutrition, Biotechnology30 enrolled1 locationNCT07121803
Recruiting
Not Applicable

Real-life Study of Changes of Gastroesophageal Reflux Disease Manifestations Due to Behavioural and Diet Adherence

Gastroesophageal Reflux DiseaseGERDGastroesophageal Erosion+3 more
Federal State Budgetary Scientific Institution "Federal Research Centre of Nutrition, Biotechnology150 enrolled1 locationNCT04255693
Recruiting
Not Applicable

Transpyloric Versus Gastric Feeding in Bronchopulmonary Dysplasia

Gastroesophageal RefluxBronchopulmonary Dysplasia
Children's Hospital of Philadelphia60 enrolled3 locationsNCT06534359
Recruiting
Phase 4

Clinical Trial for the Comparative Evaluation of Acid Suppression and Symptom Management of Gastroesophageal Reflux Disease With the Administration of Tegoprazan or Pantoprazole

Gastroesophageal Reflux Disease
Carnot Laboratories128 enrolled2 locationsNCT06991348