The Clonal Hematopoiesis & Inflammation in Vasculature Registry and Biorepository
Discovering Outcomes in Clonal Hematopoiesis: The Clonal Hematopoiesis and Inflammation in VasculaturE (CHIVE) Registry and Biorepository
Vanderbilt-Ingram Cancer Center
800 participants
Oct 28, 2020
OBSERVATIONAL
Conditions
Summary
This study will investigate the association between clonal hematopoiesis and other conditions. Clonal hematopoiesis (CH) refers to the mutations in a person's stem cells which commonly affect people as they get older. These mutations have notably been linked to increased risk of certain cancers as well as increased risk of heart disease.
Eligibility
Inclusion Criteria3
- Patient greater than or equal to 18 years old at time of consent
- Able to provide informed consent
- Idiopathic cytopenia (ICUS) or idiopathic cytoses (elevated blood counts without disease or explanation); clonal cytopenia of undetermined significance (CCUS), clonal hematopoiesis of indeterminate potential (CHIP) or individuals at higher risk for clonal hematopoiesis (ex. patients with known diagnosis of solid tumors or cardiovascular disease)
Exclusion Criteria2
- Unable to provide consent
- Diagnosis of active hematologic malignancy. For example, a diagnosis of CMML, AML, MDS, MPN; History of hematologic malignancy is NOT exclusionary if in complete remission (e.g. previous myeloma or lymphoma)
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Interventions
Blood will be taken from participants already undergoing blood collection
Undergo saliva collection
Bone marrow will be taken from participants already undergoing bone marrow collection
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06701214