Targeting Vascular INflammation in Patients With Community-Acquired Pneumonia
Targeting Vascular INflammation in Patients With Community-Acquired Pneumonia (TIN_CAP): a Multi-centre, Prospective, Randomized Control Trial
Ottawa Heart Institute Research Corporation
168 participants
Apr 8, 2026
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial is to learn if icosapent ethyl (Vascepa) works to lessen the amount of inflammation in adults diagnosed with Community-Acquired Pneumonia (CAP). The main question it aims to answer is: What is the effect of taking Vascepa on inflammation in the arteries in patients with CAP? Researchers will compare the drug Vascepa to a placebo (a look-alike submstance that contains no drug) to see if Vascepa works to reduce inflammation in patients with CAP. Participants wil: * take Vacscepa or a placebo twice a day for 6 months * Visit the clinic 3 times (baseline, 30 days, and 6 months) for checkups and tests
Eligibility
Inclusion Criteria4
- Patients who have:
- Hospitalization with CAP (defined as pulmonary infiltration using chest imaging, in addition to other clinical symptoms including fever, cough, and sputum)
- age > 18 years;
- given informed consent.
Exclusion Criteria12
- Patients who have:
- history of cancer within the last 3 years (other than a successfully treated cutaneous squamous cell or basal cell carcinoma or localized carcinoma in situ of the cervix).
- active inflammatory conditions (e.g. rheumatoid arthritis, chronic inflammatory bowel disease, SLE, systemic anti-inflammatory therapy (e.g. prednisone, methotrexate));
- pregnancy (all women of child bearing potential will have a negative BHCG test;
- breastfeeding;
- Women of childbearing potential who refuse to use two forms of contraception (this includes at least one form of highly effective and one effective method of contraception) throughout the study OR men capable of fathering a child who refuse to use contraception.
- Allergies to icosapent ethyl
- allergies to fish or shellfish
- glomerular filtration rate (GFR) <50 ml/min/1.72m2 (excluded from CTA portion)
- unable to give informed consent;
- Exclusion for CTA portion of the protocol:
- Patients with dye allergy will not undergo CTA but will have PET/CT
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Interventions
Participants randomized to the treatment arm will receive Vascepa 1000mg twice a day for 6 months.
Placebo twice daily
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06710080