The Effect of Preoperative Albumin Administration on Postoperative Acute Kidney Injury in Pediatric Patients With Hypoalbuminemia Undergoing Cardiac Surgery
The Effect of Preoperative Albumin Administration on Postoperative Acute Kidney Injury in Pediatric Patients With Hypoalbuminemia Undergoing Cardiac Surgery: A Prospective Randomized Clinical Trial
Seoul National University Hospital
190 participants
Jan 9, 2025
INTERVENTIONAL
Conditions
Summary
The study aims to evaluate whether preoperative albumin supplementation in pediatric patients with hypoalbuminemia undergoing cardiac surgery can reduce inflammatory responses and prevent acute kidney injury (AKI) following cardiopulmonary bypass.
Eligibility
Inclusion Criteria2
- Pediatric patients under 7 years of age undergoing cardiac surgery with cardiopulmonary bypass
- Preoperative serum albumin level of 4.0 g/dL or lower
Exclusion Criteria6
- abnormal preoperative creatinine level
- history of dialysis
- liver dysfunction
- diabetes
- history of hypersensitivity to albumin
- coagulation disorders
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Interventions
A 20% albumin solution is administered over one hour starting from the induction of anesthesia, using the following formula: (4.0-preoperative serum albumin (g/dL))×plasma volume (kg×0.65-0.8 dL)
The same volume of crystalloid solution as the administered albumin is infused.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06710353