FIRE-Diet: Food as an Intervention to Reduce the Effects of Woodsmoke Exposure on Respiratory Health
University of British Columbia
48 participants
Jun 17, 2025
INTERVENTIONAL
Conditions
Summary
Research suggests that consuming more fatty fish, fruits, and vegetables could potentially shield the lungs from the negative impacts of air pollution. The research team will look at whether a dietary intervention aimed at increasing intake of these foods can protect the lungs from woodsmoke as the air pollutant and look into how this works.
Eligibility
Inclusion Criteria5
- Healthy, and specifically with no respiratory disease
- Not taking any supplements, or willing to abstain from supplement use for 4-weeks prior to study start and the whole duration of the study,
- Must currently consume, on average, less than 2 servings of fish per week and fewer than 5 servings of fruits and vegetables per day based on screening questionnaires.
- Must have a null GSTM1 genotype determined at screening.
- Must be able to provide a sufficient sputum sample during the screening visit.
Exclusion Criteria9
- Pregnant or planning to become pregnant during the study period.
- Health conditions that would pose an unacceptable risk of dietary change, or conditions that are uncontrolled based on principal investigator's judgement.
- Actively attempting to lose weight.
- Frequent wood smoke exposure (e.g. at home or employment).
- Unable to store provided meals and food safely.
- Food allergies/intolerance or food aversion preventing adherence to the intervention diet, or unwillingness/medically unable to adjust diet in line with the intervention.
- Relocation during the study period to an area which will prevent food delivery.
- History of smoking tobacco, marijuana, or and other substance or vaping within the past 6 months, or having smoked the equivalent of 0.5 pack-years ever.
- Body mass index (BMI) \<18.5, as determined during the in-person screening visit.
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Interventions
Designed to increase Omega-3 Fatty Acids (Eicosapentaenoic acid (EPA), Docosahexaenoic acid (DHA)), fruit, and vegetable intake, participants will receive grocery and meal deliveries for approximately 4-weeks via online ordering with dietician counselling.
Participants will receive weekly food subsidies for their groceries for 4-weeks (\~equivalent to the subsidies to provide groceries in the Intervention arm) but are free to purchase whatever they wish. The participants will continue to have dietician counseling during this time.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06711614