InvEstigating oeStrogen Signalling and the Effect upoN the exTracelluar Matrix In pAtients With Obstructive Lung Disease

This study investigates how estrogen affects the lung's extracellular matrix (the structural scaffolding of lung tissue) in patients with obstructive lung diseases like asthma and COPD, and in healthy volunteers, to better understand sex differences in lung disease. **You may be eligible if...** - You are a man or woman over 18 years old - Women at any stage of menopause (pre, peri, or post) can participate - Healthy volunteers are included (with less than 10 pack-years of smoking history and no asthma or COPD) - You are willing and able to give informed consent **You may NOT be eligible if...** - You have active tuberculosis, HIV, Hepatitis B, or Hepatitis C - You have a history of alcohol or drug abuse, serious psychiatric conditions, or major medical/surgical history - You are pregnant - You have a serious illness with a prognosis of less than 3 years Talk to your doctor to see if this trial is right for you.