Treatment of Moderate to Severe Refractory Crohn's Disease

This study is testing a new treatment called TRX103 for moderate to severe Crohn's disease that has not responded to multiple prior therapies. Crohn's disease is a chronic inflammatory bowel condition, and this study is for patients who have already tried and failed at least two advanced treatments. **You may be eligible if...** - You are between 18 and 65 years old and weigh at least 40 kg - You have had Crohn's disease for at least 1 year, confirmed by endoscopy - Your disease is currently active and moderate to severe, based on both imaging and symptom scores - You have already tried and failed (or could not tolerate) at least 2 advanced therapies such as TNF inhibitors, anti-integrins, IL-12/23 inhibitors, or JAK inhibitors - If you are on steroids, your dose is low and stable **You may NOT be eligible if...** - You have serious infections, active tuberculosis, or a history of certain serious illnesses - You have significant liver, kidney, or heart problems - You are pregnant or unwilling to use contraception - You are currently on certain medications that could interact with the study drug Talk to your doctor to see if this trial is right for you.