RecruitingPhase 4NCT06738407

Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections

Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections Among Adolescent and Young Adult Females in the United States

Sponsor

Westat

Enrollment

760 participants

Start Date

Feb 27, 2026

Study Type

INTERVENTIONAL

Conditions

Chlamydia Syphilis Sexually Transmitted Infections (STIs)Gonorrhea

Summary

The goal of this open-label, randomized trial is to assess the efficacy of doxycycline prophylaxis in reducing incidences of bacterial sexually transmitted infections (STIs) among adolescent and young adult females while also evaluating acceptability and antimicrobial resistance in order to inform public health policy.

Eligibility

Sex: FEMALEMin Age: 13 YearsMax Age: 29 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Doxycycline hyclate delayed released 200 mg, a drug called Doxycycline hyclate delayed released 200 mg weekly, and others for people with chlamydia, gonorrhea, and other related conditions. The study is currently recruiting participants at 13 locations. People eligible for this study include women aged 13 Years to 29 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGDoxycycline hyclate delayed released 200 mg

200 mg of doxycycline taken by mouth as soon as possible and within 72 hours after any condomless oral, vaginal, and/or anal sex along with STI screening and sexual health counseling

DRUGDoxycycline hyclate delayed released 200 mg weekly

200 mg of doxycycline taken by mouth weekly regardless of sexual activity along with STI screening and sexual health counseling

OTHERPer standard of care with quarterly STI testing/treatment and sexual health counseling

Quarterly STI testing/treatment and sexual health counseling

Locations(13)

UCLA Care

Los Angeles, California, United States

San Francisco Department of Public Health

San Francisco, California, United States

Children's National Medical Center

Washington D.C., District of Columbia, United States

University of Florida

Tampa, Florida, United States

Ponce de Leon

Atlanta, Georgia, United States

University Illinois Chicago

Chicago, Illinois, United States

Tulane University

New Orleans, Louisiana, United States

Johns Hopkins University

Baltimore, Maryland, United States

Harlem Prevention Center

New York, New York, United States

Chapel Hill

Chapel Hill, North Carolina, United States

Penn Prevention

Philadelphia, Pennsylvania, United States

St. Jude Children's Research Hospital

Memphis, Tennessee, United States

Baylor College of Medicine

Houston, Texas, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

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NCT06738407

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