RecruitingNot ApplicableNCT06749847

HPV Self-sampling in the General Population

HPV Self-sampling in the General Population: Efficacy, Feasibility, Acceptability and Cost-effectiveness


Sponsor

International Agency for Research on Cancer

Enrollment

6,000 participants

Start Date

Jun 26, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

A randomized controlled trial comparing three strategies for cervical cancer screening: direct mailing of HPV self-sampling kit ("Outreach" arm), choice between self-sampling or healthcare provider sampling ("Choice" arm), and standard care (control arm) in two French departments.


Eligibility

Sex: FEMALEMin Age: 30 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This trial is studying whether offering women a home self-sampling kit for HPV testing (to detect human papillomavirus, the main cause of cervical cancer) increases participation in the national cervical cancer screening program in France. You may be eligible if: you are a woman between 30 and 65 years old; you live in the Marne or Aube departments of France; and you are receiving your first invitation (not a reminder) for the current screening round, making you at moderate risk. You may NOT be eligible if: you are outside the target age range; you have already participated in the current screening round; you have had a total hysterectomy; you have a history of cervical cancer; or you are currently being followed up for an abnormal screening result. Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERWomen receive invitation letter with HPV self-sampling kit

Direct mailing of HPV self-sampling kit. Women receive HPV self-sampling kit with instructions. SMS reminder at 3 months if no participation. Assistance provided for triage cytology if HPV positive.

OTHERWomen receive invitation letter with choice of ordering a free self-sampling kit or visit healthcare provider

Option between self-sampling and healthcare provider: women can choose testing method. If self-sampling chosen, kit sent to home. SMS reminder at 3 months if no participation.


Locations(2)

Regional Cancer Screening Coordinating Centre, Aube site

Troyes, Aube, France

Regional Cancer Screening Coordinating Centre, Marne site

Reims, Marne, France

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NCT06749847


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