HPV Self-sampling in the General Population
HPV Self-sampling in the General Population: Efficacy, Feasibility, Acceptability and Cost-effectiveness
International Agency for Research on Cancer
6,000 participants
Jun 26, 2025
INTERVENTIONAL
Conditions
Summary
A randomized controlled trial comparing three strategies for cervical cancer screening: direct mailing of HPV self-sampling kit ("Outreach" arm), choice between self-sampling or healthcare provider sampling ("Choice" arm), and standard care (control arm) in two French departments.
Eligibility
Inclusion Criteria3
- Women aged 30 to 65 years old
- Living in the study area (Departments of Marne and Aube, France)
- At moderate risk of cervical cancer, i.e. eligible to the organised programme and receiving the first invitation of the screening round (not a reminder letter)
Exclusion Criteria5
- Outside the target age (less than 30 years old, or 66 years old and more)
- Already participating in the current screening round
- Total hysterectomy
- History of cervical cancer
- Current follow-up for abnormal cervical screening result or cervical lesions
Interventions
Direct mailing of HPV self-sampling kit. Women receive HPV self-sampling kit with instructions. SMS reminder at 3 months if no participation. Assistance provided for triage cytology if HPV positive.
Option between self-sampling and healthcare provider: women can choose testing method. If self-sampling chosen, kit sent to home. SMS reminder at 3 months if no participation.
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT06749847