Simplification of Oral Sodium Loading Test in the Diagnosis of Primary Aldosteronism: 2-day Replacing 3-day Method
Consistency of 24-hour Urinary Aldosterone on on the Second Day and the Third Day in Diagnosis of Primary Aldosteronism Measured in the Oral Sodium Loading Test by Liquid Chromatography-tandem Mass Spectrometry
Peking Union Medical College Hospital
33 participants
Dec 15, 2023
OBSERVATIONAL
Conditions
Summary
To compare the consistency of 24-hour urinary aldosterone in the diagnosis of primary aldosteronism by oral sodium loading test between the second day method and the third day method
Eligibility
Inclusion Criteria10
- PA patients:
- Patients with hypertension and hypokalemia who have been diagnosed with primary aldosteronism following the latest version international guidelines for primary aldosteronism.
- Age: 20-70 years old, male and female;
- BMI: 18.5-23.9 kg/m2;
- Age: 20-70 years old, male and female;
- BMI: 18.5-23.9 kg/m2;
- Blood pressure: 90-120/60-80 mmHg on three consecutive office blood pressure readings;
- Female must have regular menstrual cycle (blood and urine samples should be taken during the non-menstrual period);
- Regular dietary habits;
- No medications taken within the past 1 month.
Exclusion Criteria8
- Other causes of endocrine hypertension including pheochromocytoma, Cushing syndrome, etc.
- Renal artery stenosis and low potassium due to other factors, such as renal tubular acidosis, Bartter syndrome, Gitelman syndrome, etc.
- History of hyperthyroidism, hepatic and renal insufficiency, malignant tumors, metabolic diseases, cardiovascular diseases, and mental diseases,menstrual disorders Healthy volunteers
- History of hypokalemia.
- History of liver and kidney dysfunction, malignant tumors, metabolic disorders, cardiovascular diseases, and psychiatric disorders, etc.
- Menstrual irregularities and taking contraceptive pills.
- History of hypertension
- Have taken any drugs including anti-inflammatory drugs, potassium diuretics, or special health products in the 4 weeks prior to the examination,
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Interventions
The subjects underwent an oral high-salt diet test with an additional 10g of salt per day for 3 consecutive days, and 24-hour urine measurements of aldosterone, sodium, potassium and creatinine were obtained on days 2 and 3
Locations(1)
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NCT06750172