RecruitingNCT06755372
The Role of Toll-like Receptor-4 in Periodontitis Patients With End-stage Renal Disease in a Sample of Egyptian Population
Sponsor
Ain Shams University
Enrollment
100 participants
Start Date
Apr 1, 2025
Study Type
OBSERVATIONAL
Conditions
Summary
Chronic kidney disease (CKD) is a significant public health issue in Egypt, leading to end-stage renal disease (ESRD). ESRD patients often suffer from oral abnormalities due to the disease and medications. Periodontitis is linked to systemic diseases, including renal disease, with inflammation playing a key role. TLR4 genetic variations may influence susceptibility to CKD and periodontitis. This study investigates the association between TLR4 \[Gly/Thr (rs2149356)\] polymorphism and chronic periodontal disease in ESRD patients in Egypt.
Eligibility
Min Age: 30 YearsMax Age: 60 Years
Inclusion Criteria12
- Group I: Healthy Subjects with Periodontitis
- Age: 30 to 60 years
- Gender: Both male and female
- Diagnosed with Periodontitis stage II and/or stage III
- Systemically healthy, no history of systemic diseases
- Not on long-term medications
- Age: 30 to 60 years
- Gender: Both male and female
- Diagnosed with end-stage renal disease (ESRD) on regular hemodialysis
- Diagnosed with Periodontitis stage II and/or stage III
- Unrelated Egyptians from a similar socioeconomic status, residing in the same geographical area
- Underlying type 2 diabetes mellitus
Exclusion Criteria7
- Smokers
- Individuals with any systemic disease or long-term medication use
- Group II: ESRD Patients with Periodontitis
- Individuals with kidney transplants
- Individuals with systemic diseases other than diabetes
- History of malignancy
- Smokers
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06755372
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