RecruitingNot ApplicableNCT06758609

To Assess the Effectiveness and Safety of Catheter-based Focal Intracranial Hypothermia Combined with Endovascular Reperfusion Therapy for Patients with Acute Anterior Circulation Large Artery Occlusion

Local Hypothermia and Endovascular Recanalization for Acute Large Artery Occlusive Stroke-A Multicenter, Prospective, Open-label, Blinded-Endpoint, Randomized Controlled Trial

Sponsor

Guangdong Second Provincial General Hospital

Enrollment

262 participants

Start Date

Dec 1, 2024

Study Type

INTERVENTIONAL

Conditions

Acute Ischemic Stroke Acute Cerebrovascular Accident Internal Carotid Artery Middle Cerebral Artery Occlusion

Summary

A multicenter, prospective, open-label, blinded-endpoint, randomized controlled trial to assess the effectiveness and safety of catheter-based focal intracranial hypothermia combined with endovascular reperfusion therapy for patients with acute anterior circulation large artery occlusion.

Eligibility

Min Age: 18 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called 4°C saline infusion, a procedure called Mechanical thrombectomy, and others for people with acute cerebrovascular accident, acute ischemic stroke, and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years to 85 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREMechanical thrombectomy

Mechanical thrombectomy

DRUG4°C saline infusion

Patients received a total of 350 ml of 4°C saline infusion in addition to mechanical thrombectomy (MT).

DRUGNormothermic saline infusion

Patients received a total of 350 ml of roomtemperature saline infusion in addition to mechanical thrombectomy (MT).

Locations(1)

Guangdong Second Provincial General Hospital

Guangzhou, Guangdong, China

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NCT06758609

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