RecruitingPhase 1NCT06764771

A Study of BMS-986488 as Monotherapy and Combination Therapy in Participants With Advanced Malignant Tumors

A Phase 1/1b Open-label Study of BMS-986488 as Monotherapy and Combination Therapy in Participants With Advanced Malignant Tumors

Sponsor

Bristol-Myers Squibb

Enrollment

437 participants

Start Date

Mar 25, 2025

Study Type

INTERVENTIONAL

Conditions

Advanced Malignant Tumors

Summary

This purpose of this study is to determine if experimental treatment with BMS-986488, alone, or in combinations is safe, tolerable, and has anti-cancer activity in patients with advanced malignant tumors.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Adagrasib, a drug called BMS-986488, and others for people with advanced malignant tumors. The study is currently recruiting participants at 8 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGBMS-986488

Specified dose on specified days

DRUGAdagrasib

Specified dose on specified days

DRUGCetuximab

Specified dose on specified days

DRUGNivolumab

Specified dose on specified days

Locations(8)

John Theurer Cancer Center at Hackensack University Medical Center

Hackensack, New Jersey, United States

Local Institution - 0020

Allentown, Pennsylvania, United States

The West Clinic, PLLC dba West Cancer Center

Germantown, Tennessee, United States

Local Institution - 0025

Dallas, Texas, United States

Local Institution - 0031

Brisbane, Queensland, Australia

BC Cancer Vancouver

Vancouver, British Columbia, Canada

Local Institution - 0015

Montreal, Quebec, Canada

Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus

Québec, Quebec, Canada

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06764771

Related Trials

To Evaluate the Tolerability and Pharmacokinetics of TQB3142 for Injection in Patients With Advanced Malignant Tumors

NCT073388385 locations

A Phase I Study of SPGL008 in Subjects With Advanced Malignant Tumors

NCT070380051 location

First-in-Human Investigation of JMT108 Injection in Participants With Advanced Malignant Tumors

NCT068776501 location

A Phase 1 Study of SSGJ-709 in Patients With Advanced Malignant Tumors

NCT070164901 location

A Clinical Trial Evaluating Injection of TQB6411 in Subjects With Advanced Malignant Tumors

NCT0704375119 locations