RecruitingNCT06770062
Multimodality Evaluation of Left Ventricular Remodeling In Mitral Regurgitation: A Pilot Study
Sponsor
Mayo Clinic
Enrollment
30 participants
Start Date
Jan 20, 2025
Study Type
OBSERVATIONAL
Conditions
Summary
The purpose of this research is to determine the feasibility of a larger, future study proposing a multimodal approach using cardiac CT and MRI to assess the risk of developing left ventricular (LV) systolic dysfunction in patients with mitral regurgitation (MR).
Eligibility
Min Age: 18 Years
Inclusion Criteria5
- Age >= 18
- Male or Female
- A diagnosis of severe chronic primary mitral regurgitation
- Undergoing isolated robotic mitral annuloplasty at Mayo Clinic Rochester
- Patients must have the ability to consent or have an appropriate representative available to do so.
Exclusion Criteria8
- Prior valve intervention,
- Concomitant valve surgery at the time of mitral annuloplasty (e.g. tricuspid annuloplasty, aortic valve replacement).
- Concomitant >= moderate regurgitation or stenosis in any other valve by preoperative echocardiography
- History of prior myocardial infarction
- History of cardiomyopathy unrelated to mitral regurgitation (e.g. dilated, hypertrophic, infiltrative)
- Pregnancy. Women of childbearing potential will be verbally screened by clinical staff during as part of routine pre-MRI evaluation. If a subject is unsure whether they could be pregnant, a negative pregnancy test will be performed prior to scanning.
- Implantable devices that would be a contraindication to MRI
- Severe allergy to gadolinium MRI contrast
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Interventions
DIAGNOSTIC_TESTCardiac MRI
Each subject will receive two cardiac MRI scans (with and without contrast), one preoperative and another 6-12 months after. The duration of each MRI is approximately 45-60 minutes
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06770062
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