RecruitingNCT06775106

Exhaled Breath: A Novel Technique for Rapid Diagnosis of Respiratory Diseases and Infections

Sponsor

Oregon Health and Science University

Enrollment

100 participants

Start Date

Nov 30, 2024

Study Type

OBSERVATIONAL

Conditions

Pulmonary Disease Critical Illness

Summary

This study aims to use mass spectrometry techniques to analyze exhaled patient breath in non-COVID ICU-admitted patients requiring ventilation for a rapid and accurate early detection of pulmonary diseases and inflammatory markers.

Eligibility

Min Age: 18 YearsMax Age: 120 Years

Inclusion Criteria1

Non-COVID-19 adult consented patients (>18yo) on ventilatory support in the ICU at OHSU

Exclusion Criteria2

Patients with "severe respiratory distress" as defined by arterial pO2 of <60 mmHg on maximal FiO2 \& optimal ventilator settings
Patient with severe hemodynamic instability as defined by (a) receiving IV infusion of 2 or more pressors or inotropic medications (Levophed, vasopressin, phenylephrine, or epinephrine) \& (b) MAP of <60 mmHg or SB <80 mmHg

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Interventions

OTHERThere is no intervention in this observational study

No direct intervention will be done to patients eligible for the study. There will be a shunt placed to divert 5-15% of exhaled breath into a collection tube. This will not affect the patient's existing standard medical care.