Spatial Fragmentation Combined With Low-dose Radiotherapy for Immunotherapy Combined With Chemotherapy-resistant Locally Advanced or Advanced Non-small Cell Lung Cancer

This study is testing a new radiation technique called spatial fragmentation (a way of delivering radiation in a targeted pattern) combined with low-dose radiotherapy for people with advanced non-small cell lung cancer (NSCLC) whose cancer has stopped responding to immunotherapy and chemotherapy. **You may be eligible if...** - You are 18 years or older - You have lung cancer confirmed by biopsy (adenocarcinoma, squamous cell, or small cell) - Your cancer has progressed after receiving immunotherapy - The area being treated has not received prior radiation, or it has been at least 6 months since last radiation to that site - You have a Karnofsky score of 70 or higher and expected survival of 3+ months **You may NOT be eligible if...** - Your cancer involves malignant fluid in the chest, abdominal cavity, or has spread to the brain lining - You had a heart attack within the past 6 months or have severe heart arrhythmia - Your tumors are not suitable for radiation targeting Talk to your doctor to see if this trial is right for you.