RecruitingNot ApplicableNCT06775782

Remote Ischemic Conditioning for Acute Moderate Ischemic Stroke Due to Large Artery Atherosclerosis

Remote Ischemic Conditioning for Acute Moderate Ischemic Stroke Due to Large Artery Atherosclerosis: A Multi-centered, Open-label, Blind Endpoint, Randomized Controlled Trial

Sponsor

First Affiliated Hospital Xi'an Jiaotong University

Enrollment

1,150 participants

Start Date

Aug 10, 2025

Study Type

INTERVENTIONAL

Conditions

Acute Ischemic Stroke

Summary

Large Artery Atherosclerosis is one of the most prevalent causes of stroke worldwide and is associated with a high risk of disability and recurrent strokes. Remote Ischemic Conditioning (RIC) is a promising therapy, and it has been recommended for further investigation in patients with acute ischemic stroke resulting from large artery atherosclerosis. The primary objective of this study is to assess the efficacy of RIC in patients suffering from acute moderate ischemic stroke due to large artery atherosclerosis.

Eligibility

Min Age: 18 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether remote ischemic conditioning (RIC) — a technique where a blood pressure cuff is repeatedly inflated and deflated on your arm or leg to temporarily reduce blood flow — can help protect the brain and reduce damage after a moderate ischemic stroke caused by a large artery blockage. **You may be eligible if...** - You are between 18 and 85 years old - You had an ischemic stroke confirmed by MRI within the past 48 hours - Your stroke is moderate in severity (NIHSS score of 6–16, or 4–5 with disabling symptoms) - Your stroke was caused by significant narrowing or blockage of a major brain artery **You may NOT be eligible if...** - More than 48 hours have passed since your stroke symptoms started - Your stroke was caused by a different mechanism (not large artery disease) - You have conditions that would prevent the arm/leg cuff technique from being safely used Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICERemote Ischemic Conditioning (RIC) treatment

RIC will be given twice a day for 10-14 days. RIC will be applied using an automated RIC device. The cuff of the RIC medical device will be placed around the bilateral upper limbs. Five cycles of cuff inflation (200mmHg for 5 minutes) and deflation (for 5 minutes) for a total procedure time of 50 minutes.

DRUGMedical Management

Patients will receive standard guideline-directed medical therapy, which will include monitor vital signs, management of blood pressure, glucose and lipids, antithrombotic therapy if appropriate.