Upper Airway Inflammation and Olfaction: Mechanisms of Loss and Recovery
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
140 participants
May 22, 2023
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial is to understand the mechanisms leading to olfactory dysfunction (OD) in chronic rhinosinusitis (CRS). The main questions it aims to answer are: * Is the type 2 inflammation impacting the olfactory epithelium regeneration, leading to OD? * Does a treatment interfering with one of the major T2 inflammatory cytokines, have an impact on the mechanisms of OD in CRS? Participants will undergo olfactory testing and nasal brushing before and after 3 months of treatment.
Eligibility
Plain Language Summary
Simplified for easier understanding
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Interventions
Nasal brushing of the olfactory cleft
Smell testing using the Sniffin' Sticks Test
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06776042