COMT and OPRM1 Polymorphisms and Their Effect on Post-Operative Pain in Children
COMT and OPRM1 Polymorphisms and Their Effect on Post-Operative Pain in Children Undergoing Orthopedic, Abdominal, Thoracic, and Plastic Surgeries.
American University of Beirut Medical Center
200 participants
Mar 10, 2025
OBSERVATIONAL
Conditions
Summary
The goal of this observational study is to investigate whether the A118G single-nucleotide polymorphism (SNP) in the mu-opioid receptor1(OPRM1) and Catechol-O-methyltransferase (COMT) SNPs influence postoperative pain scores in children between the ages of 8 and 18 undergoing orthopedic, abdominal, thoracic, and plastic surgeries. The main question\[s\] it aims to answer \[is\]: Do OPRM1 and COMT SNPs influence postoperative pain scores in children between the ages of 8 and 18 undergoing orthopedic, abdominal, thoracic, and plastic surgeries? Participants will be assessed for their pain scores, sedation level, the amount of postoperative analgesics received, duration of their stay in the post-anesthesia care unit, and toxicity.
Eligibility
Inclusion Criteria3
- All children 8 years to 18 years
- Undergoing orthopedic, abdominal, thoracic, and plastic surgeries
- American Society of Anesthesiologists classification (ASA) I-II-III
Exclusion Criteria5
- Children with schizoid personality disorders, phobias, and anxiety
- Patients with neuropathic pain associated with surgeries requiring surgical treatment.
- Children presented with all types of depressive disorders, atypical bipolar disorder, or a suspicion of substance abuse.
- American Society of Anesthesiologists classification (ASA) ≥IV
- All patients receiving regional anesthesia, local blocks, epidural and caudal blocks.
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Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06777875