RecruitingNot ApplicableNCT06778135

Neocortical Microarchitecture of Executive Function

Neocortical Microarchitecture of Executive Function Using Large-scale Intracranial Electrophysiology

Sponsor

University of Colorado, Denver

Enrollment

15 participants

Start Date

Jul 25, 2025

Study Type

INTERVENTIONAL

Conditions

Parkinson Disease

Summary

This study is being done to the determine the ability and utility of using the Neuropixels probes in the human brain. A Neuropixels probe will be inserted into and removed from the brain of awake human patients who are undergoing awake Deep Brain Stimulation (DBS) surgery.

Eligibility

Min Age: 45 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study is collecting brain tissue samples and recordings from people with Parkinson's disease who are already having deep brain stimulation (DBS) surgery. Researchers want to study the microscopic structure of the brain's outer cortex to better understand how it relates to thinking and decision-making (executive function) in Parkinson's patients. **You may be eligible if...** - You have Parkinson's disease that is not adequately controlled by medications - You are between 45 and 85 years old - You are scheduled for deep brain stimulation surgery - Your cognitive testing shows no more than mild impairment expected in Parkinson's disease - Your surgeon's plan allows the surgical approach needed for the study - You are able to be awake during part of the surgery and complete brief tasks - You can understand English instructions **You may NOT be eligible if...** - You have severe cognitive impairment or dementia - You have conditions that make the extended awake surgery unsafe or not feasible Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

PROCEDURETemporary implatation of large-scale intracranial electrode.

The Neuropixels probe (imec, Leuven, Belgium) is a new high resolution multi electrode technology that uses custom 130-nm complementary metal-oxide-semiconductor fabrication with high surface area but low-impedance titanium nitride recordings to produce high site count devices with extreme electrode density in a small package.

DEVICEbrain electrode

Show that Neuropixels can safely and effectively record from large populations of neurons.

Locations(1)

University of Colorado

Aurora, Colorado, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06778135

Related Trials

A Trial to Test the Use of Dapansutrile, an Anti-inflammatory Medication, in People With Parkinson's Disease

NCT071577351 location

Radiofrequency (RF) Ablation Prospective Outcomes Study for Central Nervous System - RAPID for CNS

NCT065536254 locations