Clinical Study of Perioperative Sleep Disorders in Cardiac Surgery
Nanjing First Hospital, Nanjing Medical University
180 participants
Oct 11, 2024
INTERVENTIONAL
Conditions
Summary
The aim of this clinical trial is to understand the effects of dexmedetomidine and esketamine on postoperative sleep in patients undergoing cardiac surgery. The main questions it aims to answer are: Does dexmedetomidine or esketamine prevent the development of postoperative sleep disturbances? Which one works better? The researchers compared dexmedetomidine and esketamine with saline (a drug-free solvent) to see if dexmedetomidine and esketamine prevented the development of postoperative sleep disturbances. Participants will: 1. Intraoperative continuous infusion of dexmedetomidine, esketamine or saline until the end of surgery 2. Postoperative sleep was assessed on the first and third postoperative days using a sleep rating scale
Eligibility
Inclusion Criteria2
- ASA class II-III, NYHA class I-III, EF ≥ 50%
- Intended to perform cardiac surgery under extracorporeal circulation
Exclusion Criteria7
- Patients undergoing second heart surgery
- Patients with mental retardation, deafness, or other conditions that interfere with normal communication
- Previous neurological or psychiatric disorders
- Patients with a history of sleep disorders
- Alcoholics, drug addicts, or psychotropic substance abusers
- Significant hepatic or renal dysfunction affecting drug metabolism
- Contraindication to the use of dexmedetomidine or esketamine.
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Interventions
Intraoperative infusion of 0.3ug/kg/h dexmedetomidine
Intraoperative infusion of 0.3mg/kg/h esketamine
Intraoperative infusion of equal volumes of saline
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT06778811