Intracoronary Optical Coherence Tomography Guidance Vs. Angiography Only Guidance for Treatment of Coronary In-stent Restenosis
IN-Stent RestenosIs Detection and TrEtment by Optical Coherence Tomography
San Luigi Gonzaga Hospital
360 participants
Sep 1, 2024
INTERVENTIONAL
Conditions
Summary
Although advances in drug-eluting stents (DES) have substantially reduced the risk of coronary in-stent restenosis (ISR) and the need for target lesion revascularisation (TLR), ISR persists. There are several treatment options for ISR (conventional balloon angioplasty, cutting or scoring balloons, drug-coated balloons, repeat DES implantation or bypass surgery). Coronary imaging is mandatory to perform PCI on ISR. Optimal coherence tomography (OCT) is an excellent option to guide PCI, but its role in ISR-PCI remains unclear. The INSIDE OCT Trial aims to compare the acute performance of PCI for ISR, either guided by OCT and angiography or by angiography alone.
Eligibility
Inclusion Criteria5
- Informed consent signed
- Age ≥ 18 years
- Referred for angiography either in stable or ACS setting suitability for PCI through femoral or radial access
- A coronary in-stent restenosis between 70% and 99% in at least two projections in a vessel with a lumen diameter ≥ 2.25 - ≤ 5.75 mm (The severity of the stenosis should be based on visual estimation, with current online state-of-the-art angiographic equipment of the participating centres and after a mandatory dose of 50-200 mcg intracoronary of nitroglycerine.
- Stable hemodynamics
Exclusion Criteria3
- Inability to give informed consent
- Participation in another clinical study with an investigational product
- OCT pullback not technically feasible in vessel site
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Using OCT to guide PCI in ISR
Locations(12)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06779110