Genotype-phenotype Relationship Between Cryptogenic Cholestasis and Familial Intrahepatic Cholestasis

This study is investigating a group of rare inherited liver conditions that cause bile to build up abnormally (cholestasis). Researchers want to better understand how genetic mutations lead to different symptoms and disease patterns in patients. **You may be eligible if...** - You are 18 or older - You have been diagnosed with PFIC (progressive familial intrahepatic cholestasis) or a related inherited liver condition causing bile flow problems - You are able to provide informed consent **You may NOT be eligible if...** - You have another documented cause of chronic liver disease that better explains your symptoms Talk to your doctor to see if this trial is right for you.