Endometriosis and Migraine
Mechanisms Underlying Endometriosis and Migraine Comorbidity
Washington University School of Medicine
120 participants
Feb 12, 2025
OBSERVATIONAL
Conditions
Summary
This study aims to determine differences in experimental pain and sex hormone levels between patients with migraine, patients with endometriosis, patients with migraine and endometriosis, and healthy controls. Participants will complete surveys, experimental pain paradigms and collection of samples for hormone analyses.
Eligibility
Inclusion Criteria4
- Patients with diagnosed endometriosis, migraine, or both endometriosis and migraine
- Healthy control subjects with no history of chronic pain
- Age 12-45
- Assigned female sex at birth
Exclusion Criteria5
- Pregnancy or breastfeeding
- Presence of prolactinoma
- Presence of psychiatric, neurological, endocrinological and/or developmental conditions and taking medications for these conditions
- Current use of dopamine agonist or SSRI medications
- For patients aged 12-17 not having a parent/legal guardian willing to sign the consent and answer surveys about their child's health
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Interventions
The Thermal Sensory Analyzer (TSA-II or PATHWAY platform - Medoc, Ramat Yishai, Israel) will be used to safely deliver heat and cold stimuli. These devices can deliver relatively complex stimuli via computer control. All targeted stimulus temperatures will be less than 50°C, and participants will be free to remove their arm or leg at any time from the thermode. Noxious cold stimuli will also be delivered with a plastic water container or a water bath (FISHER, USA). Participants will be free to pull out of the water bath at any time
Pressure stimuli will be applied by using a handheld algometer (Wagner Instruments) or the Pressure Algometer (Medoc, Ramat Yishai, Israel). These devices have a round probe that allows quantifying the amount of pressure that is being applied. The Pressure Algometer allows a real-time visual feedback to control and monitor applied pressure rates. Pressure will be applied to the lower leg, volar forearm, or trapezius.
Pain intensity and pain unpleasantness ratings will be assessed.
The CPM paradigm assesses endogenous inhibitory pain modulation efficiency. CPM testing includes the application of a "test" stimulus without conditioning (control run, pressure pain thresholds) and a subsequent application of the same test stimulus together with a conditioning stimulus (conditioning run, a 60 second of foot immersion in cold water). The CPM response is the difference in the pressure pain thresholds between the control and the conditioning runs.
Blood samples (approximately 2 tablespoons) and/or saliva and/or urine will be collected for analyses of sex hormone levels (e.g., prolactin, testosterone, estradiol).
Locations(1)
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NCT06785129