EXploratory Study on Postprandial Energy Metabolism

This Phase 2 study investigates whether taking a daily probiotic supplement for 3 months can improve how the body handles blood sugar and fats after meals in adults aged 50–70 who are moderately overweight or obese but otherwise metabolically healthy. Researchers believe that improving gut bacteria composition may benefit cardiovascular and metabolic health in this age group. Men and postmenopausal women aged 50–70 with a BMI between 27 and 34.9 and stable weight who are not diabetic, not taking medications for blood pressure or cholesterol, and not currently using probiotic supplements or foods may be eligible. Participation involves 5 clinic visits over about 3.5 months for blood tests, metabolic measurements, and stool sample collection, along with daily probiotic or placebo supplementation at home. This summary was generated by AI to help patients understand the study in plain language.