RecruitingPhase 3NCT07311850

Efficacy and Safety of MET097 Once-Weekly in People With Overweight or Obesity

Evaluating The Efficacy and Safety of MET097, a Fully-Biased, Ultra Long-Acting GLP-1RA, In People With Overweight or Obesity: A Phase 3, Multi-Center Randomized, Controlled Trial (VESPER-4)

Sponsor

Pfizer

Enrollment

3,501 participants

Start Date

Dec 19, 2025

Study Type

INTERVENTIONAL

Conditions

Obesity and Overweight

Summary

This study investigates the efficacy and safety of once weekly injectable MET097 in adult participants with obesity or overweight with weight-related comorbidities excluding T2D. This trial will last for a duration of 84 weeks. The primary endpoint will be assessed after 64 weeks of treatment with the secondary at 84 weeks.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called MET097 and a drug called Placebo for people with obesity and overweight. The study is currently recruiting participants at 195 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGMET097

Once-weekly MET097 administered via subcutaneous injection

DRUGPlacebo

Once-weekly placebo administered via subcutaneous injection

Locations(171)

Headlands Research

Scottsdale, Arizona, United States

Alliance Research Institute

Canoga Park, California, United States

Collaborative Neuroscience Research, LLC

Garden Grove, California, United States

Clinical Innovations, Inc dba CITrials

Riverside, California, United States

Peninsula Headlands LLC

Rolling Hills, California, United States

CenExcel Rocky Mountain Clinical Research, LLC

Englewood, Colorado, United States

Research Centers of America

Hollywood, Florida, United States

Future Medical Research (Civia Health)

Longwood, Florida, United States

Advanced Clinical Research

Miami, Florida, United States

Oviedo Medical Research

Oviedo, Florida, United States

CenExel FCR - ForCare Clinical Research

Tampa, Florida, United States

DelRicht Research @ Springer Wellness and Restorative Health

Atlanta, Georgia, United States

CenExel iResearch, LLC

Savannah, Georgia, United States

CenExel CBH Health

Gaithersburg, Maryland, United States

Clinical Research Professionals

Chesterfield, Missouri, United States

Civia Health St. Louis

Creve Coeur, Missouri, United States

Civia Health Independence

Independence, Missouri, United States

Upgrade Performance Institute

Elkhorn, Nebraska, United States

Quality Clinical Research Inc

Omaha, Nebraska, United States

Primary Care Research (Civia Health)

Papillion, Nebraska, United States

Hassman Research Institute

Marlton, New Jersey, United States

Forum Health Cary

Cary, North Carolina, United States

Eximia EquiHealth Research

Durham, North Carolina, United States

Sahana Optometry PLLC dba Family Eye Wellness

Holly Springs, North Carolina, United States

TMA Headlands LLC - Wilmington

Wilmington, North Carolina, United States

TMA Headlands LLC

Wilmington, North Carolina, United States

Summit Headlands LLC

Portland, Oregon, United States

Tribe Clinical Research, LLC

Spartanburg, South Carolina, United States

Civia Health Goodlettsville

Goodlettsville, Tennessee, United States

Civia Health Nashville

La Vergne, Tennessee, United States

Civia Health Memphis

Memphis, Tennessee, United States

Forum Austin (Civia Health)

Austin, Texas, United States

Cedar Health Research

Dallas, Texas, United States

GLRI El Paso Research

El Paso, Texas, United States

Dallas Clinical Research Center (Pillar Clinical Research)

Richardson, Texas, United States

Pantheon Clinical Research

Bountiful, Utah, United States

MHAT Botevgrad

Botevgrad, Bulgaria

Medical Center 4Life EOOD

Burgas, Bulgaria

Multiprofile Hospital for Active Treatment Dobrich AD (MHAT Dobrich AD)

Dobrich, Bulgaria

Medical Center New Polyclinic Gabrovo Ltd.

Gabrovo, Bulgaria

Medical Center Zdrave 1

Kozloduy, Bulgaria

Medical Center Futuremeds EOOD

Plovdiv, Bulgaria

MHAT Sveta Karidad EAD

Plovdiv, Bulgaria

Diagnostic Consultative Center Aleksandrovska

Sofia, Bulgaria

Medical Center Hera EOOD

Sofia, Bulgaria

Prevencia - 2000 - Medical Center for Prehospital Medical Care OOD

Stara Zagora, Bulgaria

Medical Center - Clinic Nova EOOD

Varna, Bulgaria

Medical Centre Pratia Clinic EOOD

Varna, Bulgaria

MC Nevromedics Ltd.

Veliko Tarnovo, Bulgaria

Medical Center Berbatov

Yambol, Bulgaria

Centricity Research Etobicoke Endocrinology

Etobicoke, Ontario, Canada

The Wharton Medical Clinic Clinical Trials Inc

Hamilton, Ontario, Canada

LMC Diabetes & Endocrinology - Bayview (Centricity Research Toronto LMC Multispecialty)

Toronto, Ontario, Canada

Centricity Research Mirabel Multispecialty (Centricity Research)

Mirabel, Quebec, Canada

Pratia Brno,s.r.o

Brno, Czechia

Nemocnice Jihlava

Jihlava, Czechia

Edumed s.r.o.

Náchod, Czechia

Agentura science pro s.r.o.

Olomouc, Czechia

CCR Ostrava

Ostrava, Czechia

Pratia Pardubice

Pardubice, Czechia

Fakultní nemocnice Královské Vinohrady

Prague, Czechia

Synexus/Trialmed Prague

Prague, Czechia

ResTrial s.r.o.

Prague, Czechia

CDG Studienambulanz Hartard

Munich, Bavaria, Germany

Studienzentrum FMZ Radowsky

Leipzig, Saxony, Germany

Zentrum für klinische Studien Bad Homburg

Bad Homburg, Germany

Klinische Forschung Berlin-Mitte GmbH

Berlin, Germany

FutureMeds Berlin

Berlin, Germany

Velocity Clinical Research Germany

Berlin, Germany

Diabetespraxis Dr. Braun

Berlin, Germany

Zentrum für klinische Forschung

Cologne, Germany

Klinische Forschung Dresden GmbH / Pratia

Dresden, Germany

Medizentrum Essen Borbeck

Essen, Germany

Praxis am Markt - Dr. Bernd Becker

Essen, Germany

Klinische Forschung Hamburg GmbH / Pratia

Hamburg, Germany

Diabetes Studienzentrum Wilhelmsburg

Hamburg, Germany

Diabeteszentrum Hamburg-West

Hamburg, Germany

Praxis Reinfeld Mitte

Holstein, Germany

Klinische Forschung Karlsruhe GmbH

Karlsruhe, Germany

AmBeNet GmbH

Leipzig, Germany

Gemeinschaftspraxis Dres. H.Kittner und K.Hartig

Naunhof, Germany

FutureMeds Frankfurt/Offenbach

Offenbach, Germany

Zentrum für klinische Forschung Allgäu-Oberschwaben

Wangen, Germany

Medislim GmbH

Weinheim, Germany

Zdrowie Osteo Medic sc L i A Racewicz, A i J Supronik

Bialystok, Poland

NZOZ Centrum Medyczne KERmed

Bydgoszcz, Poland

Centrum medyczne Pratia Bydgoszcz

Bydgoszcz, Poland

Pratia Chojnice

Chojnice, Poland

Synexus Polska Sp. z o.o., Oddzial w Czestochowie

Częstochowa, Poland

Synexus Polska Sp z o.o.

Gdansk, Poland

Centrum Badan Klinicznych PI-House Sp. z o.o.

Gdansk, Poland

Centrum Medyczne Pratia Gdynia

Gdynia, Poland

FutureMeds Gdynia

Gdynia, Poland

Synexus Polska Sp. z o.o. Oddzial w Gdyni

Gdynia, Poland

Synexus Polska Sp. Z O.O. Oddzial W Katowicach

Katowice, Poland

Centrum Medyczne Pratia Katowice

Katowice, Poland

FutureMeds Krakow

Krakow, Poland

Synexus Polska Sp. z o.o., Oddzial w Lodzi

Lodz, Poland

Centrum Terapii Współczesnej J.M. Jasnorzewska Spółka Komandytowo-Akcyjna

Lodz, Poland

FutureMeds Lodz

Lodz, Poland

Ekamed Sp. z o. o.

Lublin, Poland

FutureMeds Olsztyn

Olsztyn, Poland

Medicome Sp. z o.o. Oświęcimskie Centrum Badań Klinicznych

Oświęcim, Poland

IRMED

Piotrkow Trybunalski, Poland

Trialmed CRS

Piotrkow Trybunalski, Poland

Synexus Polska Sp. z o.o., Oddział w Poznaniu

Poznan, Poland

Praktyka Lekarska Ewa Krzyzagorska

Poznan, Poland

ETG Siedlce

Siedlce, Poland

Metabolica Sp. z o.o., NZOZ METABOLICA Ośrodek Badań Klinicznych

Tarnów, Poland

FutureMeds Warszawa Centrum

Warsaw, Poland

Instytut Diabetologii.sp.z.o.o.

Warsaw, Poland

Synexus Polska Sp. z o.o., Oddzial w Warszawie

Warsaw, Poland

Etg Warszawa

Warsaw, Poland

FutureMeds Warszawa Targowek

Warsaw, Poland

Synexus Polska Sp. z o.o., Oddział we Wrocławiu

Wroclaw, Poland

FutureMeds Wroclaw

Wroclaw, Poland

Santa Familia PTG Lodz

Lodz, Łódź Voivodeship, Poland

Minimed S.R.L.

Bacau, Romania

Futuremeds S.R.L., Brasov

Brasov, Romania

Hightech Medical Services S.R.L (Centrul pentru Studiul Metabolismului)

Bucharest, Romania

Institutul National de Endocrinologie "C.I. Parhon"

Bucharest, Romania

Institutul Clinic Fundeni

Bucharest, Romania

Fundatia Dr Victor Babes

Bucharest, Romania

Futuremeds S.R.L., Craiova

Criaova, Romania

Futuremeds S.R.L., Galati

Galati, Romania

Centru Medical "GRANDMED"

Oradea, Romania

Sc Gensan Srl/Policlinica Astra

Sibiu, Romania

Centrul Medical Mediab - Mediab Srl

Târgu Mureş, Romania

Poliklinika Váš Lekár

Bratislava, Slovakia

Medispektrum s.r.o.

Bratislava, Slovakia

DIABEDA s.r.o.

Bratislava, Slovakia

Cardio D&R Košice

Košice, Slovakia

Medical group Kosice s.r.o.

Košice, Slovakia

Tatratrial s.r.o.

Rožňava, Slovakia

MEDI-DIA s.r.o

Sabinov, Slovakia

JAL s.r.o.

Trnava, Slovakia

Medivasa s.r.o

Žilina, Slovakia

Hospital Universitario Virgen de la Victoria

Málaga, Málaga, Spain

Hospital Vithas Sevilla

Castilleja de la Cuesta, Spain

Futuremeds Spain Cadiz

Chiclana de la Frontera, Spain

Futuremeds Spain Madrid

Madrid, Spain

Hospital Virgen del Camino

Sanlúcar de Barrameda, Spain

Nuevas Tecnologías en Diabetes y Endocrinología S.L.

Seville, Spain

Futuremeds Spain Sevilla

Seville, Spain

Ecg Médica S.L.

Valencia, Spain

Ashfields Primary Care Center

Sandbach, Cheshire, United Kingdom

Civia Health Sunderland

Hendon, CITY of Sunderland, United Kingdom

FutureMeds Glasgow McCafferty House

Glasgow, Scotland, United Kingdom

Synexus Glasgow Clinical Research Centre

Bellshill, United Kingdom

Synexus Midlands Clinical Research Centre

Birmingham, United Kingdom

FutureMeds Birmingham

Birmingham, United Kingdom

Civia Health_Boots Birmingham

Birmingham, United Kingdom

Southmead Hospital

Bristol, United Kingdom

FutureMeds Liverpool

Bromborough, United Kingdom

Panthera Biopartners Limited - Enfield

Enfield, United Kingdom

Panthera Biopartners Limited - Glasgow

Glasgow, United Kingdom

Bodyline Medical Clinic, Crosby Civia Health

Liverpool, United Kingdom

FutureMeds London

London, United Kingdom

Synexus Manchester Clinical Research Centre

Manchester, United Kingdom

Kiltearn Medical Centre

Nantwich, United Kingdom

FutureMeds Newcastle upon Tyne

Newcastle upon Tyne, United Kingdom

Civia Health_Boots Nottingham

Nottingham, United Kingdom

Bodyline Medical Clinic Warrington Civia Health

Paddington, United Kingdom

Panthera Biopartners Limited - Preston

Preston, United Kingdom

Panthera Biopartners Limited - Rochdale

Rochdale, United Kingdom

Clifton Medical Centre

Rotherham, United Kingdom

Panthera Biopartners Limited - Sheffield

Sheffield, United Kingdom

Bodyline Medical Clinic, St Helens Civia Health

St Helens, United Kingdom

FutureMeds Teesside

Stockton-on-Tees, United Kingdom

Bodyline Medical Clinic, Stoke-on-Trent Civia Health

Stoke-on-Trent, United Kingdom

Panthera Biopartners Limited - York

York, United Kingdom

View Full Details on ClinicalTrials.gov

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NCT07311850

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