RecruitingNot ApplicableNCT06786390

Improved Recovery of Walking in Acquired Muscle Weakness

Regaining Walking Ability Easier and Better in Critical Illness Polyneuropathy and Myopathy


Sponsor

Fondazione Don Carlo Gnocchi Onlus

Enrollment

72 participants

Start Date

Feb 25, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The aim of Re-Walk-Easy is to evaluate the effects of rehabilitation based on electrical stimulation on the motor performance of critically ill patients. The study will also investigate the pathophysiology of the two forms-the myopathic-predominant and the polyneuropathic-predominant variants-by examining the longitudinal progression of CIP and CIM and determining which form benefits more from electrical stimulation as a rehabilitative approach.


Eligibility

Min Age: 18 YearsMax Age: 85 Years

Inclusion Criteria2

  • clinical diagnosis of tetra/paraparesis of peripheral origin as disclosed by ENG/EMG examination;
  • be independent before the episode of critical illness

Exclusion Criteria7

  • history of previous comorbidity for ICU-AW;
  • previous known chronic polyneuropathy;
  • severe coagulopathy;
  • severe disorder of consciousness;
  • contraindications to Electrical Stimulation application
  • Prosthetic implants
  • musculoskeletal, neurological, cardiovascular and pulmonary disorders that may alter the gait

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Interventions

OTHERRehabilitation protocol: FES

Subjects diagnosed with CIP will follow the FES-based rehabilitation protocol

OTHERRehabilitation protocol without FES

Subjects belonging to the control group will follow the rehabilitation protocol without FES

OTHERRehabilitation protocol: FES

Subjects diagnosed with CIM will follow the FES-based rehabilitation protocol


Locations(1)

IRCCS Fondazione Don Carlo Gnocchi Onlus

Milan, Italy

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NCT06786390


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