RecruitingNot ApplicableNCT06792877

Mindfulness for Cognition in Early-stage Alzheimer's Disease

Mechanisms of Mindfulness for Cognition in Early-Stage Alzheimer's Disease

Sponsor

VA Boston Healthcare System

Enrollment

100 participants

Start Date

Jan 23, 2025

Study Type

INTERVENTIONAL

Conditions

Aging Mild Cognitive Impairment (MCI)Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease TBI (Traumatic Brain Injury)Healthy Elderly Alzheimer&Amp;Amp;#39;s Dementia (AD)

Summary

The goal of this clinical trial is to learn if mindfulness meditation can improve outcomes in older adults with and without cognitive impairment. The main questions it aims to answer are: 1. How does mindfulness impact thinking and memory? 2. How does mindfulness influence brain function and structure? 3. How does mindfulness affect daily function and quality of life? Researchers will compare all outcomes to one other groups. In one group, individuals will participate in a mindfulness class intervention; in the other group, individuals will not engage in any active interventions immediately, but will be placed on a waitlist for the mindfulness intervention. Researchers will compare all outcomes between the groups groups to determine whether the mindfulness interventions leads to greater improvement compared to no intervention (waitlist group). Participants will: * Be randomly assigned to participate in the mindfulness intervention, or no immediate intervention (waitlist) * Complete paper-and-pencil cognitive testing, surveys, computerized tasks, and neuroimaging measures (EEG and MRI) before and after the intervention Outcomes will be assess at baseline, 2 months, 4 months and 6 months.

Eligibility

Min Age: 50 YearsMax Age: 100 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether online mindfulness meditation programs can help preserve and improve memory and thinking skills in older adults — including those with early-stage Alzheimer's disease or mild cognitive impairment (early memory problems that have not yet become full dementia). **You may be eligible if...** - You are an older adult with normal cognition, mild cognitive impairment (MCI), or subjective cognitive decline (you notice memory changes even if tests are normal) - You have access to a computer or smartphone with internet - You can understand the consent form **You may NOT be eligible if...** - You do not have a computer, smartphone, or internet access - You have moderate or severe dementia - You have had a stroke, Parkinson's disease, or another serious neurological condition - You have been hospitalized in the past 5 years for mood disorders, alcohol, or drug use Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALMindfulness Intervention

The Mindfulness Intervention is an adapted form of Mindfulness-based stress reduction (MBSR) training virtual class that meets for 10 weeks. The class involves mindfulness training using awareness and focused attention, group discussion of the experience, and mindful movement. The Mindfulness Intervention also includes daily home practice using mindfulness recordings.

BEHAVIORALWaitlist then mindfulness

Participants in this arm will first wait 10 weeks and then complete a mindfulness course with outcome measures assessed at baseline, after 10 weeks wait list and then after mindfulness course.