TBI (Traumatic Brain Injury) Clinical Trials

24 recruitingLast updated: June 18, 2026

There are 24 actively recruiting tbi (traumatic brain injury) clinical trials across 5 countries. Studies span Not Applicable, Phase 2, Phase 1, Early Phase 1, Phase 3. Top locations include Minneapolis, Minnesota, United States, Rennes, France, Boston, Massachusetts, United States. Updated daily from ClinicalTrials.gov.


TBI (Traumatic Brain Injury) Trials at a Glance

24 actively recruiting trials for tbi (traumatic brain injury) are listed on ClinicalTrialsFinder across 6 cities in 5 countries. The largest study group is Not Applicable with 10 trials, with the heaviest enrollment activity in Minneapolis, Rennes, and Boston. Lead sponsors running tbi (traumatic brain injury) studies include University of Minnesota, University of Texas Southwestern Medical Center, and Children's Hospital Los Angeles.

Browse tbi (traumatic brain injury) trials by phase

Treatments under study

About TBI (Traumatic Brain Injury) Clinical Trials

Looking for clinical trials for TBI (Traumatic Brain Injury)? There are currently 24 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new TBI (Traumatic Brain Injury) trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about TBI (Traumatic Brain Injury) clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 24 trials

Recruiting

fNIRS for Disorders of Consciousness

comaBrain InjuryDisorders of Consciousness+4 more
University of California, Los Angeles55 enrolled1 locationNCT07485361
Recruiting

Individual Cerebral Hemodynamic Oxygenation Relationships (ICHOR 1)

TBITBI (Traumatic Brain Injury)Hemodynamic Instability+2 more
Children's Hospital Los Angeles1,000 enrolled1 locationNCT06195345
Recruiting
Phase 3

Efficacy of Early Continuous Infusion of HSS on the Neurological Outcome at 6 Months in TBI Patients.

TBI (Traumatic Brain Injury)
Nantes University Hospital760 enrolled23 locationsNCT07319208
Recruiting

Long Lasting Effect of Hyperbaric Oxygen Therapy on Cognitive Function in Traumatic Brain Injury Patients

TBI (Traumatic Brain Injury)
Assaf-Harofeh Medical Center100 enrolled1 locationNCT07430150
Recruiting
Early Phase 1

Stimulating After Recovery From Traumatic Brain Injury

TBI (Traumatic Brain Injury)
University of Minnesota30 enrolled1 locationNCT05327829
Recruiting
Not Applicable

Cognitive Rehabilitation for Refugees With Traumatic Brain Injury and Cognitive Impairment

TBI (Traumatic Brain Injury)Cognitive Symptoms
Massachusetts General Hospital50 enrolled1 locationNCT06839079
Recruiting

Brain Development in Young Children Following Mild Traumatic Brain Injury - Pilot Study

TBI (Traumatic Brain Injury)
Institut National de la Santé Et de la Recherche Médicale, France60 enrolled1 locationNCT06024122
Recruiting
Not Applicable

Depth Electrode Detection of Cortical Spreading Depolarization After Traumatic Brain Injury

TBI (Traumatic Brain Injury)
University of Minnesota15 enrolled1 locationNCT05205174
Recruiting
Not Applicable

Transcutaneous Auricular Neurostimulation for ICU Patients With Traumatic Brain Injury

TBI (Traumatic Brain Injury)
University of Texas Southwestern Medical Center42 enrolled1 locationNCT06467708
Recruiting

Augmented Renal Clearance in Neurocritical Care

Ischemic StrokeIntracerebral HemorrhageTBI (Traumatic Brain Injury)+4 more
University of Alberta512 enrolled3 locationsNCT07410624
Recruiting

Emergency Department Implementation of the i-STAT Alinity Traumatic Brain Injury Whole Blood Test

TBI (Traumatic Brain Injury)Implementation Research
Shawn Eagle340 enrolled1 locationNCT07373509
Recruiting
Not Applicable

Cognitive Remediation in Forensic Mental Health Care

DepressionCognitive DysfunctionAnxiety+9 more
The Royal Ottawa Mental Health Centre30 enrolled1 locationNCT04610697
Recruiting
Phase 2

Veterans' Cognitive Function, Mental Health, and Quality of Life After Hyperbaric Oxygen Therapy

PTSD - Post Traumatic Stress DisorderTBI (Traumatic Brain Injury)Post Concussive Syndrome
Summit Hyperbarics and Wellness54 enrolled1 locationNCT07214415
Recruiting
Not Applicable

Evaluation of Decision-Making Fatigue After Traumatic Brain Injury

TBI (Traumatic Brain Injury)
University of Minnesota40 enrolled1 locationNCT07103200
Recruiting

Cerebral Autoregulation, Brain Perfusion, and Neurocognitive Outcomes After Traumatic Brain Injury

TBITBI (Traumatic Brain Injury)Brain Injury Traumatic Severe+2 more
University of Texas Southwestern Medical Center130 enrolled3 locationsNCT06480838
Recruiting

Biomarkers in the Brain Oxygen Optimization in Severe Traumatic Brain Injury Trial

TBI (Traumatic Brain Injury)
University of Pennsylvania300 enrolled2 locationsNCT04565119
Recruiting
Not Applicable

Behavioral Treatment of Insomnia in Active-Duty Service Members With Traumatic Brain Injury

InsomniaTBI (Traumatic Brain Injury)
Noctem, LLC168 enrolled1 locationNCT06867666
Recruiting
Phase 1Phase 2

Evaluating the Impact of Adjuvant Use of Beta Blockers on Clinical Outcomes in Patients With Traumatic Brain Injury

TBI (Traumatic Brain Injury)
Mansoura University100 enrolled2 locationsNCT06836856
Recruiting
Phase 1

DBS for Cognitive Deficits After Traumatic Brain Injury

TBI (Traumatic Brain Injury)
Sunnybrook Health Sciences Centre10 enrolled1 locationNCT06818864
Recruiting
Not Applicable

Mindfulness for Cognition in Early-stage Alzheimer's Disease

AgingMild Cognitive Impairment (MCI)Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease+3 more
VA Boston Healthcare System100 enrolled1 locationNCT06792877