RecruitingNot ApplicableNCT06802939

RTMS for Refractory Auditory Hallucinations Based on Personalized Targets Using Magnetoencephalography

Sponsor

Shanghai Mental Health Center

Enrollment

36 participants

Start Date

Feb 5, 2025

Study Type

INTERVENTIONAL

Conditions

Schizophrenia Refractory Auditory Hallucinations

Summary

This study is an before-after study in the same patient, which enrolled 36 psychiatric patients with refractory auditory hallucinations. The target of patient intervention relies on the results of magnetoencephalography localization. The medication and dosage remain unchanged during the intervention period. The investigators assume that the intervention targets for each auditory hallucination patient are individualized.

Eligibility

Min Age: 13 YearsMax Age: 55 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a brain stimulation technique called rTMS (repetitive transcranial magnetic stimulation) guided by personalized brain scan imaging (MEG) to reduce persistent auditory hallucinations — hearing voices — in patients with schizophrenia who have not responded to multiple antipsychotic medications. **You may be eligible if...** - You have a clinical diagnosis of schizophrenia - You are right-handed - You have completed at least primary school education - You have persistent auditory hallucinations despite trying at least 3 antipsychotic medications for 6 months - You or your guardian can sign the informed consent form **You may NOT be eligible if...** - You have had electroconvulsive therapy (ECT) in the past 3 months - You have significant physical neurological conditions (brain injury, sensory/motor disorders) - You have a metal implant in your skull or other contraindications to rTMS - You have epilepsy or a pacemaker Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICErTMS

RTMS using pseudo stimulus intervention in weeks 1-2, for a total of 10 days. After resting for 2 weeks, enter the 3-4 weeks of real stimulation, with 5 days of intervention per week for a total of 10 days. Application of rTMS for 1Hz low-frequency intervention, with intervention parameters of 1400 sessions, 100% exercise threshold, and a total of 23 minutes per session. After each target intervention, rest for half an hour to one hour.