RecruitingNot ApplicableNCT06804109

Non-invasive Vagus Nerve Stimulation (nVNS) and Cognition in Young Adult Vapers - A Pilot Study

Vaping and Vagal Neuromodulation of Cognition

Sponsor

Temple University

Enrollment

100 participants

Start Date

Mar 18, 2025

Study Type

INTERVENTIONAL

Conditions

Vaping

Summary

The purpose of this study is to assess the effects of non-invasive vagus nerve stimulation (nNVS) on cognitive functioning in the users of e-cigarettes or vaping products. The investigators will use a digital wellness companion product (TRUVAGA™ device) that provides mild transcutaneous nVNS. The participants will be randomized to receive either a 2-min nNVS stimulation or control stimulation in the neck region followed by completion of three cognitive tests of attention and executive function.

Eligibility

Min Age: 18 YearsMax Age: 25 Years

Inclusion Criteria3

Healthy young adults
Age range 18-25 years
Current or prior users of e-cigarettes

Exclusion Criteria20

Participants will be excluded from the study if they:
Have any rash, infection, swelling, cut, soreness, drug patch, surgical scar on the neck area
Have any implantable medical device in their body such as a pacemaker, hearing aid implant, or any other metallic/electronic device
Have any hearing or vision problems that are not corrected
Are pregnant or breastfeeding
Have any learning disabilities
Have a medical history of any of the following condition
Meningitis
Traumatic brain injury
Seizure
Syncope
Schizophrenia
Schizoaffective disorder
Bulimia (eating disorder)
Other serious neurological illness
Have a medical history of any of the following cardiac disorder
Carotid atherosclerosis or carotid artery disease
Cervical vagotomy
First degree atrioventricular block or prolonged QT interval
Are taking any medications for to treat hypertension, arrhythmias, or are on calcium channel blockers