RecruitingNCT06819969

The Canadian Lung Outcomes in Users of Vaping Devices Study

The Canadian Lung Outcomes in Users of Vaping Devices (CLOUD) Study

Sponsor

University of British Columbia

Enrollment

500 participants

Start Date

Jul 25, 2025

Study Type

OBSERVATIONAL

Conditions

Vaping Vaping Teens Small Airways Diseases Vaping Related Disorder Vaping Behavior

Summary

Vaping is increasingly popular with both adolescent and adult Canadians, but the long-term health impacts remain unknown. We believe that the tools we currently have to detect lung disease in people who vape may be insufficient and propose new ways to find lung injuries that may impact them over the course of their lives. These include exercise testing, new imaging techniques, and new breathing tests that will demonstrate how vaping may harm their lungs. We will use these tools in both adolescent and adult Canadians to give Canadians who vape important information on the consequences of vaping.

Eligibility

Min Age: 12 Years

Inclusion Criteria6

Adolescent arm:
Aged ≥12 and \<19 years old
Either 1) use neither combustible cigarettes nor e-cigarettes or 2) use e-cigarettes exclusively
Adult arm:
Aged ≥19 years old
Fall into one of the following categories: 1) use neither combustible cigarettes nor e-cigarettes; 2) use combustible cigarettes exclusively, never using e-cigarettes; 3) use e-cigarettes exclusively, never using combustible cigarettes; or 4) use both combustible cigarettes and e-cigarettes currently

Exclusion Criteria12

Adolescent arm:
Contraindication to pulmonary function testing and cardiopulmonary exercise testing
Have smoked combustible cannabis within the last month and/or have a combustible cannabis smoking history of \>1 joint-year
Have smoked combustible cigarettes within the last 6 months
Have a physician-diagnosed chronic lung disease (such as asthma, cystic fibrosis, or bronchopulmonary dysplasia)
Inability to provide written informed consent
Adult arm:
Contraindication to pulmonary function testing and cardiopulmonary exercise testing
Have smoked combustible cannabis within the last month and/or have a combustible cannabis smoking history of \>1 joint-year
Currently undergoing treatment for lung cancer
Inability to provide written informed consent
No limitations will be placed on the type of e-liquids used by participants; e.g., e-cigarette users of nicotine, tetrahydrocannabinol, and cannabidiol will be all enrolled.