Systemic and Tumor Immune Response During Pelvic (Chemo)Radiation and/or Brachytherapy for Cervical Cancer

This study is examining how the body's immune system responds during radiation therapy (with or without chemotherapy) for cervical cancer, by collecting extra blood and tissue samples for research purposes. **You may be eligible if...** - You are 18 or older and have been diagnosed with locally advanced cervical cancer or another gynecologic cancer requiring radiation to the pelvis - You are scheduled to receive pelvic radiation, with or without chemotherapy or internal radiation (brachytherapy) - You have not previously received radiation to the pelvis or chemotherapy for this cancer - You are willing to have extra blood draws and biopsies taken for research **You may NOT be eligible if...** - You have a serious medical condition that would prevent you from completing the full treatment course - You have a weakened immune system or an active infection - You are on immune-suppressing medications for another medical condition - You are planned to receive immune checkpoint therapy (immunotherapy drugs like pembrolizumab) Talk to your doctor to see if this trial is right for you.