Impact of Depression on Thermoregulation

This study is examining how depression affects the body's ability to regulate temperature during exercise — specifically comparing people without depression, people with untreated depression, and people with depression being treated with antidepressants. **You may be eligible if...** - You are between 18 and 40 years old - You either have no depression, OR have been clinically diagnosed with major depressive disorder (whether untreated or taking a serotonin-based antidepressant for at least 2 weeks) - You have normal blood pressure and are not diabetic - You are in average physical fitness for your age and sex - You are proficient in English **You may NOT be eligible if...** - Your BMI is above 35 - You are pregnant or planning to become pregnant in the next year - You smoke or use recreational drugs - You have a latex or adhesive allergy - You take medications that could affect heart rate or temperature regulation (such as beta blockers or diuretics) - You experience chest pain or significant musculoskeletal pain during exertion Talk to your doctor to see if this trial is right for you.