RecruitingNCT06807840

Flu Infection at UPHS

Evaluating Immune Imprinting in the Context of Influenza Virus Infections

Sponsor

University of Pennsylvania

Enrollment

50 participants

Start Date

Jan 27, 2025

Study Type

OBSERVATIONAL

Conditions

Influenza, Human

Summary

Cellular and humoral immune responses in individuals with active influenza infection will be assessed. Each year, up to 50 participants will be enrolled. The investigators hypothesize that influenza infection will elicit mostly memory immune responses rather than de novo immune responses to infection.

Eligibility

Min Age: 18 Years

Inclusion Criteria4

Provision of signed and dated informed consent form
Stated willingness to comply with all study procedures and availability for the duration of the study
Aged 18 years and older
Influenza positive test result performed within the University of Pennsylvania Health System

Exclusion Criteria11

Known latex allergy
Immunosuppression as a result of an underlying illness or treatment with immunosuppressive or cytotoxic drugs, or use of anticancer chemotherapy or radiation therapy within the preceding 36 months
Pregnancy due to the volume of blood collected in this study
Treatment with immunoglobulin or another blood product within the 3 months prior to enrollment in this study
Any neoplastic disease (excluding non-melanoma skin cancer or prostate cancer that is stable in the absence of therapy) or a history of any hematological malignancy ("active" is defined as having received treatment within the past 5 years)
Known acute or chronic medical condition that, in the opinion of the investigator or appropriate sub-investigator, would interfere with the evaluation of immune responses
Intends to donate blood during the study period
A known human immunodeficiency virus, hepatitis B, or hepatitis C infection
Any condition that would, in the opinion of the site investigator, place the subject at an unacceptable risk of injury or render the subject unable to meet the requirements of the protocol
Prolonged inpatient hospitalization that disrupts or interferes with study procedures.
Weigh less than 110lbs