Comparison of Clomid and Lezra With Lezra for Ovulation Induction in Clomid Resistant PCOS Case
A RCT Comparing the Effectiveness of a Combination Therapy of Lezra and Clomid Versus Lezra Alone for Inducing Ovulation in Women Diagnosed With Clomiphene Citrate Resistant Polycystic Ovarian Syndrome
HITEC-Institute of Medical Sciences
42 participants
Jun 7, 2024
INTERVENTIONAL
Conditions
Summary
Clomiphene citrate resistant i.e failure to ovulate after 6 cycles of ovulation induction effects 15-40% of patients with PCOS.Two treatment groups will be formed one recieving letrozole alone and another recieving CC and letrozole combined.Mature follicles and endometrial thickness will be checked by transvaginal ultrasound and results will be recorded.
Eligibility
Inclusion Criteria1
- women of 20-40 years with a history of PCOS and resistant to CC
Exclusion Criteria4
- Premature ovarian insufficiency
- Husband has oligo azoospermia
- Hypothyroidism
- Hyperprolactinemia
Interventions
clomiphene citrate 100mg once daily along with letrozole 5mg to one group and letrozole 5mg to second group
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06813118