RecruitingNot ApplicableNCT06815887

Adding Magnesium Sulfate to Local Anesthetic in Combined Pectoral Nerve and Stellate Ganglion Block for Postoperative Pain Control After Modified Radical Mastectomy

Effect of Adding Magnesium Sulfate to Local Anesthetic in Combined Pectoral Nerve and Stellate Ganglion Block for Postoperative Pain Control After Modified Radical Mastectomy

Sponsor

Cairo University

Enrollment

70 participants

Start Date

Jan 15, 2024

Study Type

INTERVENTIONAL

Conditions

Postoperative Pain Modified Radical Mastectomy Magnesium Sulfate Local Anesthetic Stellate Ganglion Block Pectoral Nerve

Summary

We aim to study the effect of adding magnesium sulfate as an adjuvant to the local anesthetic used in the combined Pectoralis Nerve Block II (PECS II) and stellate ganglion block for postoperative pain control in patients undergoing modified radical mastectomy.

Eligibility

Min Age: 18 Years

Inclusion Criteria5

Age ≥18 years.
Female gender.
American Society of Anesthesiologists (ASA) physical status II or III.
Patients scheduled for elective modified radical mastectomy for breast cancer.
Body mass index (BMI): \> 20 kg/m2 and \< 40 kg/m2.

Exclusion Criteria8

Bleeding tendency due to coagulopathy,
Patients with opioid dependence or alcohol or drug abuse,
Significant liver and renal sufficiency
Patients with psychiatric illnesses that prevent them from proper perception and assessment of pain.
Local infection at the site of the block.
Known hypersensitivity or allergy to magnesium sulfate or local anesthetics.
Patients with chronic pain syndromes or pre-existing neuropathic pain conditions.
Pregnant or lactating individuals.

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Interventions

DRUGBupivacaine

Patients received the combined pectoralis nerve block II (PECS II) (20 mL) and stellate ganglion block (5 mL) using 0.5% bupivacaine (local anesthetic) without magnesium sulfate.

DRUGBupivacaine + Magnesium sulfate

Patients received the combined (20 mL) pectoralis nerve block II (PECS II) and stellate ganglion block (5 mL) using 0.5% bupivacaine (local anesthetic) mixed with 2.5 mL magnesium sulfate (10%), i.e., 250 mg.