RecruitingEarly Phase 1NCT06816459

Sensory Tests of Cigarettes for Identification of Flavors in Current Daily Smoking Adults

Sensory Evaluation of Cigarettes Claiming Removal of Menthol as a Characterizing Flavor


Sponsor

Roswell Park Cancer Institute

Enrollment

30 participants

Start Date

Oct 14, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This clinical trial tests how well current daily smoking adults can identify flavors of cigarettes. Menthol cigarettes account for 31 percent of cigarettes sold in the United States. Flavors such as menthol play an important role in the start and continued use of tobacco products. Two ways users experience flavor is through smell and taste. Menthol has cooling and numbing properties that can increase perceptions of smoothness and reduce the perceived harshness of smoke. Menthol adds a taste and aroma commonly described as "minty". The effect of menthol flavoring on smoking behavior has been studied. Use of menthol cigarettes has been associated with greater nicotine dependence and is associated with both fewer quit attempts and lower odds of quit success. In 2022, the Food and Drug Administration proposed to restrict the use of menthol as a flavor in cigarettes. Menthol has already been banned in Canada, the United Kingdom and the European Union. In late 2022, a restriction on all flavored tobacco products went into effect in California (CA), prompting the tobacco industry to introduce substitute products that did not contain menthol. It is important to find out whether New York (NY) adult smokers who smoke menthol cigarettes can identify and characterize flavors in the same cigarette brand as sold in NY versus CA following the ban of menthol cigarettes in 2022.


Eligibility

Min Age: 21 YearsMax Age: 55 Years

Inclusion Criteria4

  • Aged 21-55 years old
  • Current daily smoker of factory-made menthol cigarettes
  • General good health (assessed by self-rated health item)
  • Completion of Brief Smell Identification Test (B-SIT) with no identification of deficits

Exclusion Criteria7

  • Daily concurrent use of other tobacco products (e.g., e-cigarettes, cigars, smokeless tobacco)
  • Known allergies to mint (peppermint, spearmint), menthol
  • Self-reported olfactory or taste deficits
  • Pregnant or nursing participants, as indicated by self-report
  • History of medications known to interfere with sense of smell
  • Positive diagnosis of coronavirus 2019 (COVID-19) within 10 days of enrollment
  • Current upper respiratory infection or sinus congestion (e.g., cold, flu, seasonal allergies) (by self report)

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Interventions

OTHERCigarette smell test

Undergo cigarette smell test of 16 cigarettes in vials, then rate the overall smell on a 5 pt scale (not at all, a little noticeable, noticeable, clearly/very noticeable , do not know what this is).

OTHERCigarette Taste Test

Participants will be present 3 vials , each containing a cigarette and sample in order specified on label, then complete a coolness measure on a 0-100 visual analog scale.

OTHERStudy questionnaires

Sensory questionnaires will be administered using a web based application


Locations(1)

Roswell Park Cancer Institute

Buffalo, New York, United States

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NCT06816459


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