RecruitingNot ApplicableNCT06829654

Cryopreserved Ovarian Tissue Transplantation in Patients Who Have Survived Sarcomas and Hematological Tumors

Safety Assessment Of Cryopreserved Ovarian Tissue Transplantation In Patients Who Have Survived Sarcomas And Hematological Tumors


Sponsor

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Enrollment

80 participants

Start Date

Aug 12, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The study aims to test for the presence or absence of primary tumor-specific tumor markers in ovarian tissue. Therefore, there will be a first phase in which pathology-specific markers will be identified in the patients' diagnostic pathological material by histological, immunohistochemical, and molecular analysis; then, tumor markers will be sought in cryopreserved ovarian tissue.


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 38 Years

Plain Language Summary

Simplified for easier understanding

This study is for women who survived blood cancers or sarcomas (bone and soft tissue cancers) and had their ovarian tissue frozen before cancer treatment. It examines whether re-implanting that frozen ovarian tissue can restore hormone function and/or fertility after cancer treatment is complete. **You may be eligible if...** - You previously had ovarian tissue frozen (cryopreserved) before or during cancer treatment - You were diagnosed with Ewing sarcoma, synovial sarcoma, acute lymphoblastic leukemia, acute myeloid leukemia, chronic myeloid leukemia, or myelodysplastic syndrome - Your cancer doctor has approved the reimplantation procedure - For the cryopreservation group: you were between 18 and 37 years old at the time of freezing - For the reimplantation group: you have been cancer-free for at least 5 years **You may NOT be eligible if...** - Your cancer is still active or you have not reached the required remission milestone - Your cancer doctor objects to the procedure due to risk of cancer cells in the ovarian tissue - You do not meet the age or remission criteria Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERStep 1

Cryopreservation of ovarian tissue

OTHERStep 2

Analysis of tumor markers in the primary tumor

OTHERStep 3

Search for neoplastic cells in cryopreserved ovarian tissue

OTHERStep 4

Cryopreserved ovarian tissue autotransplantation


Locations(1)

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Bologna, Italy

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NCT06829654


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