Cabozantinib With Ifosfamide in Relapsed/Refractory Sarcomas

This study is testing a combination of two drugs — cabozantinib (a targeted therapy) and ifosfamide (a chemotherapy) — in people with sarcoma (a type of cancer affecting bones or soft tissues) that has come back or stopped responding to previous treatment. **You may be eligible if...** - You have been diagnosed with any type of sarcoma (bone or soft tissue) - Your cancer has relapsed (come back) or stopped responding to prior chemotherapy - You have measurable disease that can be tracked on imaging - You meet the required age and organ function criteria **You may NOT be eligible if...** - You have not previously received standard chemotherapy for sarcoma - Your cancer cannot be measured on imaging - Your heart, liver, or kidney function does not meet the required thresholds - You have conditions that prevent safe use of these drugs Talk to your doctor to see if this trial is right for you.