Sarcomas Clinical Trials

4 recruiting

Frequently Asked Questions

Common questions about Sarcomas clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 24 trials

Recruiting
Phase 1

Phase 1a/b Study of ZL-6201 Safety, PK, and Preliminary Efficacy in Sarcoma and Selected Tumors

Solid TumorsSarcomas
Zai Lab (Shanghai) Co., Ltd.180 enrolled2 locationsNCT07374848
Recruiting
Phase 2

A Phase 2 Trial of Zanzalintinib in Advanced/Metastatic Bone Sarcomas (ZAMBONE)

Bone Sarcomas
M.D. Anderson Cancer Center70 enrolled1 locationNCT07193550
Recruiting
Phase 1

A Phase I Trial of Combination Gemcitabine and Nab-Sirolimus in Advanced Leiomyosarcomas or Advanced Soft-Tissue Sarcomas With TSC2 or TSC1 Loss-of-function Mutations or Deletions

LeiomyosarcomaSoft Tissue Sarcomas
M.D. Anderson Cancer Center18 enrolled1 locationNCT06308419
Recruiting
Phase 2

A Study to Evaluate Tabelecleucel in Participants With Epstein Barr Virus (EBV) Associated Diseases

LeiomyosarcomaSolid Organ Transplant ComplicationsLymphoproliferative Disorders+8 more
Pierre Fabre Medicament190 enrolled40 locationsNCT04554914
Recruiting
Phase 3

Multi-center Study of TBI-1301 (INN: Mipetresgene Autoleucel; Mip-cel) in Patients With NY-ESO-1 Positive Synovial Sarcoma

Synovial Sarcomas
Takara Bio Inc.5 enrolled2 locationsNCT07174427
Recruiting
Phase 2

Hypofractionated, 3-week, Preoperative Proton or X-ray Radiotherapy for Patients With Localized Soft Tissue Sarcoma

Soft Tissue Sarcoma AdultLeiomyosarcomaSynovial Sarcomas+6 more
Oslo University Hospital110 enrolled4 locationsNCT07169344
Recruiting
Phase 2

Dose-escalated, Hypofractionated, Definitive Proton Radiotherapy for Patients With Inoperable Soft Tissue Sarcoma.

Soft Tissue Sarcoma (STS)Soft Tissue Sarcoma AdultSynovial Sarcomas+7 more
Oslo University Hospital40 enrolled2 locationsNCT07173972
Recruiting
Phase 2

IO Combined With AI as First-line Treatment for Patients With Soft Tissue Sarcoma(TAIS)

AngiosarcomaLeiomyosarcomaDesmoplastic Small Round Cell Tumor+4 more
Fudan University45 enrolled1 locationNCT06849986
Recruiting

Diagnostic and Therapeutic Targets in Cartilaginous Tumours

ChondrosarcomasCartilage Tumours
St. Anne's University Hospital Brno, Czech Republic300 enrolled1 locationNCT07315542
Recruiting
Not Applicable

Intrathecal Dexmedetomidine-Fentanyl Combination Versus Fentanyl Alone as Adjuvant to Bupivacaine in Spinal Anesthesia for Above Knee Amputation in Sarcomas of Lower Extremity

DexmedetomidineSarcomasIntrathecal+5 more
National Cancer Institute, Egypt58 enrolled1 locationNCT07276867
Recruiting
Not Applicable

CINSARC Signature and Correlation With Hemotherapy Efficacy in Soft-tissue Sarcomas. A Biomarker Study.

Soft Tissue Sarcomas
Institut Bergonié205 enrolled10 locationsNCT02789384
Recruiting
Phase 1

Cabozantinib With Ifosfamide in Relapsed/Refractory Sarcomas

OsteosarcomaEwing SarcomaSarcomas
Children's Hospital of Philadelphia30 enrolled4 locationsNCT06156410
Recruiting

Financial Toxicity in Patients With Resected Soft Tissue and Bone Sarcomas

Financial ToxicityBone Sarcomas
M.D. Anderson Cancer Center100 enrolled1 locationNCT07215611
Recruiting
Phase 1

AOH1996 for the Treatment of Refractory Solid Tumors

Pancreatic CancerOvarian CancerNon-small Cell Lung Cancer+4 more
City of Hope Medical Center92 enrolled2 locationsNCT05227326
Recruiting

A French Multicenter Observational Retrospective Study of Rare Primary Liver Cancers

CholangiocarcinomaHepatoblastomaFibrolamellar Carcinoma+7 more
Federation Francophone de Cancerologie Digestive150 enrolled40 locationsNCT06541652
Recruiting
Phase 1Phase 2

Sequential Infusion of CD146-Targeted and HER2-Targeted CAR T Cells in Patients With Advanced Sarcomas

SarcomaSarcoma, SynovialSarcoma,Soft Tissue+6 more
Essen Biotech60 enrolled1 locationNCT07066982
Recruiting
Phase 2

Study of Magnetic Resonance Image and Computed Tomography-Guided Stereotactic Body Radiation Therapy for Abdominopelvic Sarcomas (MARS Trial)

Abdominopelvic Sarcomas
Jonsson Comprehensive Cancer Center20 enrolled1 locationNCT06436612
Recruiting
Phase 2

Hypofractionated Radiotherapy Followed by Surgical Resection in the Treatment of Soft Tissue Sarcomas

Soft Tissue Sarcomas
Vanderbilt-Ingram Cancer Center40 enrolled1 locationNCT04506008
Recruiting
Phase 1

Disulfiram With Copper Gluconate and Liposomal Doxorubicin in Treatment-Refractory Sarcomas

Relapsed Sarcomas
Case Comprehensive Cancer Center24 enrolled1 locationNCT05210374
Recruiting
Phase 1Phase 2

Multicohort Trial of Different Schemes of PM14 in Monotherapy and in Combination with Radiotherapy in Soft Tissue Sarcomas and Other Solid Tumor

Advanced Solid TumorAdvanced Soft Tissue SarcomaAdvanced L-sarcomas+2 more
Grupo Espanol de Investigacion en Sarcomas195 enrolled4 locationsNCT05146440