RecruitingPhase 1NCT06840678

Home-based Transcranial Static Magnetic Field Stimulation (tSMS) of the Supplementary Motor Area in Parkinson's Disease

Patogénesis Cortical De La Enfermedad De Parkinson: Efectos Corticales Y Corticoestriatales De La Estimulación Transcraneal Por Campo Magnético Estático En Pacientes Con Enfermedad De Parkinson

Sponsor

Fundación de investigación HM

Enrollment

20 participants

Start Date

Oct 1, 2022

Study Type

INTERVENTIONAL

Conditions

Parkinson's Disease

Summary

This is a pilot open study to test the hypothesis that home-based transcranial static magnetic field stimulation (tSMS) of the supplementary motor area is safe and feasible to modulate corticostriatal activity in patients with Parkinson's disease.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Inclusion Criteria2

idiopathic Parkinson's disease (Brain Bank criteria)
optimal clinical response to dopaminergic medication (\>30% MDS-UPDRS-III improvement)

Exclusion Criteria3

MRI-incompatible metal objects in the body (e.g. cardiac pacemakers)
presence of levodopa-induced dyskinesias
other main neuropsychiatric co-morbidity

Interventions

DEVICETranscranial static magnetic field stimulation (tSMS) of the supplementary motor area

Transcranial static magnetic field stimulation (tSMS) is a non-invasive brain stimulation (NIBS) technique that decreases cortical excitability. Static magnetic fields suitable for tSMS are obtained with commercially available neodymium magnets. The investigators will use a cylindrical neodymium magnet of 60 mm diameter and 30 mm of thickness (MAG60r; Neurek SL, Toledo, Spain), which will be applied with south polarity to the supplementary motor area (SMA) using an ergonomic helmet (MAGsv1.1, Neurek SL, Toledo, Spain).